Amorphous Mesoporous Iron Aluminophosphate Catalyst for the Synthesis of 1,5-Benzodiazepines

Catalyst-free synthesis of novel 1,5-benzodiazepines and 3,4-dihydroquinoxalines using isocyanide-based one-pot, three- and four-component reactions

“…They have also been shown to be pesticidal 28 and to inhibit aldose reductase 29,30 There are several procedures reported for the synthesis of benzodiazepines which mainly include the use of catalysts. The catalysts or stoichiometric reagents employed include zeolites, 31 BF 3 ·OEt 2 , 32 Sc(OTf) 3 , 33 MgO/POCl 3 , 34 H-MCM-22, 35 FeAlP-550, 36 H 3 PMo 12 O 40 and H 3 PW 12 O 40 , 37 CH 3 COOH 38 and ZrOCl 2 , 39 amongst others. These methods pose drawbacks such as high temperatures, generation of heavy metal waste, hazardous solvents, long reaction times and relatively expensive reagents.…”

Green and efficient method for the synthesis of 1,5-benzodiazipines using phosphate fertilizers as catalysts under free solvent

“…It is known that the most classical synthesis method for 1,5-benzodiazepines is the condensation of o-phenylenediamines with -unsaturated carbonyl compounds in the presence of a wide variety of Lewis-acid catalysts [15][16][17][18][19][20][21][22][23][24][25][26] .…”

Mn/Al2O3 and Mn/ZrO2 as selective catalysts for the synthesis of bis(indolyl)methanes: The role of surface acidity and particle morphology

“…It is well established that a mixture of alumina or zirconia and a transition metal oxide exhibit higher acidity and hence better catalytic activity than individual oxides in organic transformations. In the recent past we have investigated the activity of different kinds of heterogeneous catalysts in the synthesis of industrially and biologically important organic molecules [8][9][10][11][12].…”