Amperometric Detection of Ranitidine Using Glassy Carbon Modified with Ruthenium Oxide Hexacyanoferrate Adapted in a Flow Injection System

Araújo, Wanderley Pereira de; Paixão, Thiago R.L.C.

doi:10.1002/elan.201100102

Cited by 10 publications

(6 citation statements)

References 32 publications

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“…A wide range of methods for its determination has been developed and are available in literature. Among these methods, spectrophotometry [6][7][8], liquid chromatography [9][10][11][12], titrimetry and UV spectrophotometry [13], polarography [14], cyclic voltammetry [15, 16,], flow-injection extraction-spectrophotometry [17], amperometry [18,19] have reported for data.…”

Section: Introductionmentioning

confidence: 99%

Flow injection analysis of ranitidine based on derivatization reaction producing 2‐Methylfuran cation as a sensitive and selective amperometric detector

et al. 2023

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A new electrochemical sensor in a flow injection system is developed for the determination of ranitidine in pharmaceutical formulations. The method is based on the deamination reaction of ranitidine in an acidic environment in the presence of nitrite ions producing the electroactive species 2-methylfuran and releasing nitrosamine [1]. A wide linear range of ranitidine from 4.4 to 6000 mg L À 1 , with correlation coefficient R 2 = 0.996 and the detection limit 1.3 mg L À 1 was obtained. The method has been applied in tablet analysis and ampoules; the results are within the confidence limits with 95 % reliability compared to the reference method with HPLC.

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Section: Introductionmentioning

confidence: 99%

Flow injection analysis of ranitidine based on derivatization reaction producing 2‐Methylfuran cation as a sensitive and selective amperometric detector

et al. 2023

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“…5,7 The preparation of hexacyanoferrate films with ruthenium also has been reported. Generally, the formed films on the elec-trode surface exhibit high electrocatalytic activity in the cathodic reduction of H 2 O 2 12 and anodic oxidation of ethyl alcohol, 13,14 isopropyl alcohol, 13 L-cysteine, 13 epinephrine, 15 ranitidine, 16 hydrazine, 17 deoxyguanosine, 18 ascorbic acid, 13,15 uric acid, 15 sulfite. 19 New type mixed-valent ruthenium oxide/hexacyanoruthenate film modified electrodes were applied successfully for electrocatalytic oxidation of NADH, dopamine, SO 3 2-, S 2 O 3 2and hydrazine.…”

Section: Introductionmentioning

confidence: 99%

Ruthenium Oxide Hexacyanoferrate as an Effective Electrode Modifier for Amperometric Detection of Iodate and Hydrogen Peroxide

Dodevska

Shterev

Lazarova

et al. 2020

ACSi

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Ruthenium oxide hexacyanoferrate (RuOHCF) film was electrochemically deposited onto a glassy carbon (GC) surface using consecutive cyclic voltammetry as a facile and green synthetic strategy. The electrochemical behaviour and electrocatalytic properties of the modified electrode RuОHCF/GC were evaluated with regards to electroreduction of hydrogen peroxide and iodate in a strong acidic medium (pHs 1.0–2.0) by using different electrochemical techniques, including cyclic voltammetry and amperometry at a constant potential. Electrochemical studies indicated that RuОHCF/GC possess a high catalytic activity in both studied reactions, fast response and good reproducibility of the current signal. The RuОHCF/GC exhibits enhanced electrocatalytic behaviour compared with other modified electrodes reported before. The simple and reproducible procedure for electrode fabrication, the wide linear range, anti-interference performance and long-time stability of the RuОHCF/GC make it a promising sensing material for practical quantitative determination of hydrogen peroxide and iodate. Remarkably, the reported modified electrode provided superior sensitive (1050 μA mM–1 cm–2) and highly selective amperometric detection of iodate.

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“…There are several procedures reported in literature for ranitidine determination based on chromatographic 6,7 , UV-Vis spectroscopy [8][9][10] and voltammetric methods [11][12][13] . British Pharmacopeia 14 describes the dosage of RAN-HCl in pharmaceutical formulations for quality control by liquid chromatography using potassium dihydrogen phosphate buffer and acetonitrile as mobile phase with UV detection.…”

Section: Introductionmentioning

confidence: 99%

Simple, fast and inexpensive method for determination of ranitidine hydrochloride based on conductometric measurements

Bindewald¹,

Rosa-Sobrinho²,

Bergamini³

et al. 2018

Eclet. Quim. J.

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This work aims the development and optimization of an alternative method for ranitidine hydrochloride (RAN-HCl) determination. The proposed method was based on conductometric titration of RAN by precipitation of AgCl solid using a solution of AgNO3 as titrant. It was investigated the possibility of performing the titrations on hydroalcoholic and deionized water medium. A limit of detection of 1.0 mmol L-1 and 0.5 mmol L-1 were achieved for RAN titration in deionized water and in a 75:25 hydroalcoholic mixture, respectively. Such behavior is attributed to the dielectric constant of hydroalcoholic medium, which is lower than aqueous solution, making AgCl more insoluble and improving the resolution of the conductivity curve around the end point. Therefore, it is concluded that the conductometric titration method to determine RAN using AgNO3 as titrant proved to be feasible at low drug concentrations. The statistical calculations for obtained results suggested good precision for the conductometric method. According to t-test, there were no significant differences between found values at a 95% confidence level. Moreover, obtained results showed an excellent performance of the proposed method on quality control of RAN-HCl in generic formulations without any sample pretreatment.

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Amperometric Detection of Ranitidine Using Glassy Carbon Modified with Ruthenium Oxide Hexacyanoferrate Adapted in a Flow Injection System

Cited by 10 publications

References 32 publications

Flow injection analysis of ranitidine based on derivatization reaction producing 2‐Methylfuran cation as a sensitive and selective amperometric detector

Flow injection analysis of ranitidine based on derivatization reaction producing 2‐Methylfuran cation as a sensitive and selective amperometric detector

Ruthenium Oxide Hexacyanoferrate as an Effective Electrode Modifier for Amperometric Detection of Iodate and Hydrogen Peroxide

Simple, fast and inexpensive method for determination of ranitidine hydrochloride based on conductometric measurements

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