Amphetamine behavioral sensitization and the excitatory amino acids

Karler, Ralph; Chaudhry, Imtiaz A.; Calder, Larry D.; Turkanis, Stuart A.

doi:10.1016/0006-8993(90)90341-8

Cited by 181 publications

(60 citation statements)

References 13 publications

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“…Most research has studied this process using locomotor sensitization as a model (Kilbey and Ellinwood, 1977;Karler et al, 1989Karler et al, , 1990Kalivas and Duffy, 1993a, b;Vanderschuren et al, 1999), and a number of labs are now examining the link between psychostimulantinduced locomotor activation and self-administration. For example, self-administration of cocaine produces sensitization to the locomotor-activating effects (Hooks et al, 1994;Phillips and Di Ciano, 1996;Zapata et al, 2003;Ben-Shahar et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Rapid and Persistent Sensitization to the Reinforcing Effects of Cocaine

Morgan

Liu

Roberts

2005

Neuropsychopharmacol

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The development of drug addiction involves a transition from recreational use to compulsive drug seeking and taking, and this progression can occur rapidly with cocaine use. These data highlight the importance of early drug exposure and the development of drug dependence; however, little experimental attention has been paid to this phenomenon in animal models of drug abuse. The present experiments demonstrate a progressive and rapid sensitization to the reinforcing strength of cocaine assessed using a progressive ratio (PR) schedule in rats. The first experiment found that rats show increased breakpoints over a 2-week period following acquisition. Subsequent experiments examined the role of total cocaine intake during the initial exposure period and found that low intakes (20 mg/ kg/day Â 5 days) resulted in sensitization, whereas relatively higher intake (60 or 100 mg/kg/day Â 5 days) suppressed the development of sensitization. In contrast, this higher level of intake (60 mg/kg/day Â 5 days) only transiently suppressed the expression of sensitization. Examination of breakpoints maintained by various doses of cocaine revealed an upward and leftward displacement of the cocaine doseeffect curve, relative to nonsensitized animals. These studies describe a form of sensitization that occurs rapidly to the reinforcing effects of cocaine, and provide a model to study the potential impact of initial experience on the development of drug dependence.

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Section: Discussionmentioning

confidence: 99%

Rapid and Persistent Sensitization to the Reinforcing Effects of Cocaine

Morgan

Liu

Roberts

2005

Neuropsychopharmacol

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“…For example, ionotropic glutamate receptor antagonists had no effect on acute amphetamine-induced behavioral activity but completely suppressed amphetamine-induced striatal neuropeptide gene expression (Wang et al, 1994a, b). This dissociation is understandable if one considers that glutamate neurotransmission plays a greater role in behavioral sensitization induced by repeated stimulant administration than in behaviors induced by acute stimulant administration (Karler et al, 1990;Vanderschuren and Kalivas, 2000). The question remains as to why baclofen infusions into the VTA or NA would affect CPu gene expression or infusion into the SN would affect NA gene expression.…”

Section: Baclofen Effects On Amphetamine-induced Neuropeptide Gene Exmentioning

confidence: 99%

Intracerebral Baclofen Administration Decreases Amphetamine-Induced Behavior and Neuropeptide Gene Expression in the Striatum

Zhou

Mailloux

McGinty

2004

Neuropsychopharmacol

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In a previous study, systemic administration of the GABA B receptor agonist, R-( þ )-baclofen (2.5 mg/kg, i.p.) blocked acute amphetamine (2.5 mg/kg, i.p.)-induced rearing and neuropeptide (preprodynorphin (PPD), preprotachykinin (PPT), preproenkephalin (PPE), and secretogranin II (SGII)) mRNA expression in the striatum (Zhou et al, 2004). The purpose of the present study was to investigate the site(s) of action of these baclofen effects in the dorsal and ventral striatal circuitries. Infusion of baclofen (75 ng/side) into the ventral tegmental area (VTA), substantia nigra (SN), nucleus accumbens (NA), caudate-putamen (Cpu), or medial prefrontal cortex (mPFC) had no effect on behavioral activity in saline-treated rats habituated to a photocell apparatus. However, intra-VTA infusion of baclofen (75 ng/ side) completely blocked, whereas intra-NA and intra-SN infusion of baclofen attenuated, amphetamine-induced vertical activity without affecting amphetamine-induced total distance traveled. In contrast, intramedial PFC and intra-CPu infusion of baclofen had no effect on behavioral activity in amphetamine-treated rats. Infusion of baclofen into the VTA, NA, or SN decreased amphetamine-induced neuropeptide gene expression in the striatum. These results indicate that GABA B receptor stimulation within the ventral striatal circuitry is involved in mediating acute amphetamine-induced behaviors and neuropeptide gene expression in the dorsal and ventral striatum. The present study provides information on the potential targets in the brain for baclofen in the initial behavioral and genomic response to amphetamine.

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“…As in the case of sensitization (Karler et al, 1989(Karler et al, , 1990Wolf and Khansa, 1991;Stewart and Druhan, 1993;Wolf and Jeziorski, 1993;Wolf et al, 1994), NMDA receptor antagonists are able to interfere with recovery from partial lesions (Emmi et al, 1996). D1/ D5 DA receptor antagonists also interfere with the development of sensitization when given before each injection of amphetamine Drew and Glick, 1990;Vezina, 1996), and there is one report that the antagonist interferes with the development of sensitization when given after each injection of amphetamine (Kuribara, 1995).…”

Section: Discussionmentioning

confidence: 99%

“…These long-lasting neuronal changes that accompany behavioral sensitization of the effects of amphetamine suggest a permanent reorganization within the system. It was of interest that, as is the case for recovery from partial lesions of the substantia nigra (SN), the development of sensitization to amphetamine is blocked by NMDA receptor antagonists (Karler et al, 1989(Karler et al, , 1990Wolf and Khansa, 1991;Stewart and Druhan, 1993;Wolf and Jeziorski, 1993;Wolf et al, 1994).…”

mentioning

confidence: 99%

Behavioral and Neurochemical Recovery from Partial 6-Hydroxydopamine Lesions of the Substantia Nigra Is Blocked by Daily Treatment with D1/D5, But Not D2, Dopamine Receptor Antagonists

1997

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To determine whether D1/D5 dopamine (DA) receptors play a role in normalization of DA extracellular levels of striatal DA and behavioral recovery after partial 6-OHDA lesions of the substantia nigra, animals were treated on days 1-8 after lesioning with the D1/D5 DA receptor antagonists SCH 23390 (0.1 mg/ kg, s.c.) and SCH 39166 (1.0 mg/kg, s.c.), the inactive enantiomer SCH 23388 (0.1 mg/kg, s.c.), the D2 antagonist eticlopride (0.1 mg/kg, i.p.), or saline. Spontaneous turning behavior was assessed on days 3 and 15. Basal extracellular DA and metabolites were measured in both striata using microdialysis on days 16 and 17, 8 -9 d after termination of drug treatments. On day 3, all animals turned ipsilateral to the lesion. On day 15, animals previously treated with either saline, eticlopride, or SCH 23388 showed no behavioral asymmetries, whereas animals treated with SCH 23390 or SCH 39166 turned ipsilaterally. On days 16 and 17, extracellular DA did not differ on the two sides in animals treated with saline or eticlopride and were higher on the lesioned side after SCH 23388. In animals treated with the D1/D5 receptor antagonists, however, basal levels of DA were lower on the lesioned side, showing no evidence of normalization. These results suggest a role for the D1/D5 DA receptor in the development of compensatory changes in the DA neurons that accompany behavioral recovery from partial lesions of nigrostriatal DA system.

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Amphetamine behavioral sensitization and the excitatory amino acids

Cited by 181 publications

References 13 publications

Rapid and Persistent Sensitization to the Reinforcing Effects of Cocaine

Rapid and Persistent Sensitization to the Reinforcing Effects of Cocaine

Intracerebral Baclofen Administration Decreases Amphetamine-Induced Behavior and Neuropeptide Gene Expression in the Striatum

Behavioral and Neurochemical Recovery from Partial 6-Hydroxydopamine Lesions of the Substantia Nigra Is Blocked by Daily Treatment with D1/D5, But Not D2, Dopamine Receptor Antagonists

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