Amphetamine-type stimulant use and the risk of injury or death as a result of a road-traffic accident: A systematic review of observational studies

Hayley, Amie C.; Downey, Luke A.; Shiferaw, Brook; Stough, Con

doi:10.1016/j.euroneuro.2016.02.012

Cited by 23 publications

(16 citation statements)

References 39 publications

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“…Within the still ongoing debate on the safety of recreational abuse of MDMA [61][62][63][64][65][66] our results, obtained using high doses of MDMA alone in a controlled experimental environment without concurrent different psychoactive substances, could help to provide evidence as to whether the use of amphetamine-like substances such as MDMA could acutely impair some functions (visual, acoustic, tactile responses, sensorimotor integration) that are fundamental in many facets of life (driving and workplace performance).…”

Section: Discussionmentioning

confidence: 83%

“…On the one hand, these authors report that limited and not univocal experimental data exist, showing that amphetamine-type substances can reduce certain behavioural and cognitive domains which are significant for driving ability, thus potentially leading to an increased risk of traffic accidents and fatalities. On the other hand, other authors do not report such an association [64,65]. Finally, it has to be kept in mind that MDMA is often consumed in typical environmental conditions (dance clubs, rave parties, sleep deprivation) [5] that may interfere with MDMA effects [7].…”

Section: Discussionmentioning

confidence: 99%

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MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity

et al. 2018

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Purpose MDMA is a psychoactive drug that has been increasingly abused worldwide, due to its entactogenic properties. However, concerns on its safety exist, particularly regarding its effects on attentional skills and performance. Evidence from the literature shows contrasting effects of MDMA. It generally acts as a pshychomotor stimulant, thus improving arousal and psychomotor function. However, MDMA has been demonstrated to negatively influence other skills. Consequently, human activities that require alertness, and accurate and quick reflexes (i.e. driving, operations at the workplace, etc.) could be negatively affected. In the present study, the effect of MDMA (0.1-20 mg/kg, intraperitoneally) on sensorimotor and startle/ prepulse inhibition responses was evaluated in a controlled rodent experimental setting. Methods Sensorimotor studies, evaluation of visual, acoustic, and tactile responses, evaluation of spontaneous locomotion, startle and repulse inhibition analyses were performed in an experimental controlled rodent model (rats and mice), following the administration of MDMA (0.1-20 mg/kg) intraperitoneally. Results Our findings show that all the MDMA-treated animals had impaired sensorimotor and prepulse inhibition responses compared to the control subjects at the early (5, 30 and 60 min) testing time points while all the effects disappeared, respectively, 6, 16 and 24 h post-MDMA treatment. Conclusions Within the ongoing debate on the safety of recreational abuse of MDMA, our results reveal acute prominent changes in sensorimotor and attentional performance, sensor response to external stimuli, and locomotor activity due to a single administration of a dose of MDMA (corresponding to a dose producing in humans both 'desirable' entactogenic effects and physiological adverse effects).

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 99%

MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity

et al. 2018

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“…The methodological quality assessment of each study by the Newcastle‐Ottawa Scale (Table S5, online supporting information) showed that 12 articles achieved a score of at least seven stars, indicating high quality . The other 10 studies received at least five stars .…”

Section: Resultsmentioning

confidence: 99%

Risk factors for neonatal brachial plexus palsy: a systematic review and meta‐analysis

Looven

Roy

Tanghe

et al. 2019

Develop Med Child Neuro

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Aim To provide a comprehensive update on the most prevalent, significant risk factors for neonatal brachial plexus palsy (NBPP). Method Cochrane CENTRAL, MEDLINE, Web of Science, Embase, and ClinicalTrials.gov were searched for relevant publications up to March 2019. Studies assessing risk factors of NBPP in relation to typically developing comparison individuals were included. Meta‐analysis was performed for the five most significant risk factors, on the basis of the PRISMA statement and MOOSE guidelines. Pooled odds ratios (ORs), 95% confidence intervals (CIs), and across‐study heterogeneity (I2) were reported. Reporting bias and quality of evidence was rated. In addition, we assessed the incidence of NBPP. Results Twenty‐two observational studies with a total sample size of 29 419 037 live births were selected. Significant risk factors included shoulder dystocia (OR 115.27; 95% CI 81.35–163.35; I2=92%), macrosomia (OR 9.75; 95% CI 8.29–11.46; I2=70%), (gestational) diabetes (OR 5.33; 95% CI 3.77–7.55; I2=59%), instrumental delivery (OR 3.8; 95% CI 2.77–5.23; I2=77%), and breech delivery (OR 2.49; 95% CI 1.67–3.7; I2=70%). Caesarean section appeared as a protective factor (OR 0.13; 95% CI 0.11–0.16; I2=41%). The pooled overall incidence of NBPP was 1.74 per 1000 live births. It has decreased in recent years. Interpretation The incidence of NBPP is decreasing. Shoulder dystocia, macrosomia, maternal diabetes, instrumental delivery, and breech delivery are risk factors for NBPP. Caesarean section appears as a protective factor. What this paper adds The overall incidence of neonatal brachial plexus palsy is 1.74 per 1000 live births. The incidence has declined significantly. Shoulder dystocia, macrosomia, maternal diabetes, instrumental delivery, and breech delivery are the main risk factors. Prevention is difficult owing to unpredictability and often labour‐related risk.

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“…Interestingly, motor vehicle accidents (MVAs) attributed to methamphetamine use are also not represented in the included articles. Studies reviewing the risk of MVA due to methamphetamine use suggest that the behaviour associated with methamphetamine use puts the driver at more risk of having an accident while under the influence (Hayley, Downey, Shiferaw, & Stough, ; Sheridan et al., ).…”

Section: Discussionmentioning

confidence: 99%

Rates and features of methamphetamine‐related presentations to emergency departments: An integrative literature review

Jones

Woods

Usher

2018

Journal of Clinical Nursing

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Amphetamine-type stimulant use and the risk of injury or death as a result of a road-traffic accident: A systematic review of observational studies

Cited by 23 publications

References 39 publications

MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity

MDMA alone affects sensorimotor and prepulse inhibition responses in mice and rats: tips in the debate on potential MDMA unsafety in human activity

Risk factors for neonatal brachial plexus palsy: a systematic review and meta‐analysis

Rates and features of methamphetamine‐related presentations to emergency departments: An integrative literature review

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