Amphidinolide P from the Brazilian octocoral Stragulum bicolor

Sousa, Thiciana S.; Nuzzo, Genoveffa; Torres, Maria Conceição M.; Lopes, Norberto P.; Jimenez, Paula Christine; Santos, Eduardo Natalino dos; Gomes, Bruno Alexandre Quadros; Sardo, Angela; Pessoa, Otília Deusdênia Loiola; Costa-Lotufo, Letı́cia V.; Fontana, Angelo

doi:10.1016/j.bjp.2015.08.010

Cited by 10 publications

(13 citation statements)

References 17 publications

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“…891 Finally, amphidinolide P, originally reported from the marine dinoagellate Amphidinium sp., was isolated from the octocoral Stragulum bicolor and also in its predator, the nudibranch Marionia limceana. 892 A likely artifactual methyl acetal derivative of amphidinolide P was also isolated from the octocoral.…”

Section: Cnidariansmentioning

confidence: 98%

Marine natural products

et al. 2017

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Covering: 2015. Previous review: Nat. Prod. Rep., 2016, 33, 382-431This review covers the literature published in 2015 for marine natural products (MNPs), with 1220 citations (792 for the period January to December 2015) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1340 in 429 papers for 2015), together with the relevant biological activities, source organisms and country of origin. Reviews, biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

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Section: Cnidariansmentioning

confidence: 98%

Marine natural products

et al. 2017

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“…Comprising nine genera, these nudibranchs are noted to sequester metabolites from their prey. 334,335 The macrolactone amphidinolide P (104), was isolated from the octocoral Stragulum bicolor and its nudibranch predator Marionia limceana from Brazil. 335 Prior to this isolation, 104 has only been isolated from laboratory cultures of the marine dinoagellate Amphidinium sp.…”

Section: Tritonioideamentioning

confidence: 99%

“…334,335 The macrolactone amphidinolide P (104), was isolated from the octocoral Stragulum bicolor and its nudibranch predator Marionia limceana from Brazil. 335 Prior to this isolation, 104 has only been isolated from laboratory cultures of the marine dinoagellate Amphidinium sp. 336 but S. bicolor appears to host a diverse but so far uncultivable dinoagellate community and 104 was present in much higher concentration in the octocoral than was reported in Amphidinium sp.…”

Section: Tritonioideamentioning

confidence: 99%

“…Although 104 was passed up trophic levels to Marionia limceana, no evidence was presented that it was actively sequestered and despite it having been reported as possessing moderate cytotoxicity, 336 104 was found to be inactive when tested against the HCT-116 cell line in this study. 335 A series of six terpenoid metabolites has been isolated from two nudibranch populations of Tochuina tetraquetra 337 (T. gigantea 423 ). Specimens from Port Hardy, British Columbia were noted to contain tochuinyl acetate (105), dihydrotochuinyl acetate (106), rubifolide (107) and pukalide (108).…”

Section: Tritonioideamentioning

confidence: 99%

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The chemistry and chemical ecology of nudibranchs

Dean

Prinsep

2017

Nat. Prod. Rep.

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Covering: up to the end of February 2017Nudibranchs have attracted the attention of natural product researchers due to the potential for discovery of bioactive metabolites, in conjunction with the interesting predator-prey chemical ecological interactions that are present. This review covers the literature published on natural products isolated from nudibranchs up to February 2017 with species arranged taxonomically. Selected examples of metabolites obtained from nudibranchs across the full range of taxa are discussed, including their origins (dietary or biosynthetic) if known and biological activity.

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“…91 Amphidinolide P (213, Figure 25) has been isolated from the nudibranch Marionia limceana which preys on the coral S. bicolor. 88 …”

Section: Mollusksmentioning

confidence: 99%

Natural Products from Marine Invertebrates and Microorganisms in Brazil between 2004 and 2017: Still the Challenges, More Rewards

Ióca¹,

Nicácio²,

Berlinck³

2018

J. Braz. Chem. Soc.

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The Brazilian marine biodiversity represents a unique, yet underexplored resource of biologically active compounds. This review provides an analysis of the development of marine natural products chemistry in Brazil within the period comprised between 2004 and 2017. Emphasis is directed towards marine invertebrate and marine microorganisms metabolites, including isolation, structure analysis, biosynthesis, bioactivities and total synthesis. An overview of the research on marine natural products by Brazilian researchers is also discussed, as well as perspectives for the development of the chemistry of marine natural products in Brazil.

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Amphidinolide P from the Brazilian octocoral Stragulum bicolor

Cited by 10 publications

References 17 publications

Marine natural products

Marine natural products

The chemistry and chemical ecology of nudibranchs

Natural Products from Marine Invertebrates and Microorganisms in Brazil between 2004 and 2017: Still the Challenges, More Rewards

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