Amphiphilic galactomannan nanoparticles trigger the alternative activation of murine macrophages

Peled, Ella; Sosnik, Alejandro

doi:10.1016/j.jconrel.2021.10.017

Cited by 19 publications

(23 citation statements)

References 65 publications

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“…The drug-free amphiphilic polymeric NPs can be recognized by macrophage surface receptors (e.g. lectin-like receptors) polarize M1 macrophages to the M2 macrophage, as confirmed by the downregulation of the M1 marker (CD80) and the upregulation of M2 markers (CD163 and CD206) (95). Zhao et al constructed Fe3O4@C/MnO2 NPs, which show promising photothermal functions and magnetic and catalytic activities, and can be implemented to induce M2-type macrophages to polarize to M1-type macrophages (158).Therefore, active intervention of engineered NPs in the M1-M2 macrophage polarization process could be applied to sepsis therapies.…”

Section: Nano-molecular Drugs Targeting Macrophagementioning

confidence: 87%

“…Hydrophilic (37). In the immunosuppression stage, the host often dies due to organ dysfunction (132), and nanomaterials can induce macrophage proinflammatory reaction to improve the survival rate of patients (95). iE-DAP is a drug that promotes intracellular receptor NOD1 activation and induces pro-inflammatory factor gene expression, but cannot be internalized by macrophage.…”

Section: Polymeric Nps As Drug Carriers Target Macrophagesmentioning

confidence: 99%

“…NPs promote macrophage reprogramming. Peled et al designed drug-free amphiphilic polymeric NPs generated by the self-assembly of hydrolyzed galactomannan (hGM)-linked copolymers (95). The drug-free amphiphilic polymeric NPs can be recognized by macrophage surface receptors (e.g.…”

Section: Nano-molecular Drugs Targeting Macrophagementioning

confidence: 99%

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Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management

Song

Gao

et al. 2022

Front. Immunol.

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Sepsis is a life-threatening organ dysfunction resulting from dysregulated host responses to infection. Macrophages play significant roles in host against pathogens and the immunopathogenesis of sepsis, such as phagocytosis of pathogens, secretion of cytokines, and phenotype reprogramming. However, the rapid progression of sepsis impairs macrophage function, and conventional antimicrobial and supportive treatment are not sufficient to restore dysregulated macrophages roles. Nanoparticles own unique physicochemical properties, surface functions, localized surface plasmon resonance phenomenon, passive targeting in vivo, good biocompatibility and biodegradability, are accessible for biomedical applications. Once into the body, NPs are recognized by host immune system. Macrophages are phagocytes in innate immunity dedicated to the recognition of foreign substances, including nanoparticles, with which an immune response subsequently occurs. Various design strategies, such as surface functionalization, have been implemented to manipulate the recognition of nanoparticles by monocytes/macrophages, and engulfed by them to regulate their function in sepsis, compensating for the shortcomings of sepsis traditional methods. The review summarizes the mechanism of nanomaterials targeting macrophages and recent advances in nanomedicine targeting macrophages in sepsis, which provides good insight for exploring macrophage-based nano-management in sepsis.

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Section: Nano-molecular Drugs Targeting Macrophagementioning

confidence: 87%

Section: Polymeric Nps As Drug Carriers Target Macrophagesmentioning

confidence: 99%

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Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management

Song

Gao

et al. 2022

Front. Immunol.

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“…It was demonstrated that the hybrid hydrogels activated anti-inflammatory macrophages by causing significant reduction of NO. In a study by Peled et al [ 127 ], amphiphilic nanoparticles were produced by the self-assembly of a copolymer of hydrolyzed galactomannan, a natural polysaccharide of galactose and mannose, grafted with poly(methyl metacrylate). By measuring M1 and M2 markers, the results suggested that these nanoparticles can polarize towards the M2-like phenotype.…”

Section: Nanomedicines Targeting Macrophages For Wound Healingmentioning

confidence: 99%

Recent advances in nanomedicines for regulation of macrophages in wound healing

Joorabloo

Liu

2022

J Nanobiotechnol

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Macrophages are essential immune cells and play a major role in the immune response as pro-inflammatory or anti-inflammatory agents depending on their plasticity and functions. Infiltration and activation of macrophages are usually involved in wound healing. Herein, we first described macrophage polarization and their critical functions in wound healing process. It is addressed how macrophages collaborate with other immune cells in the wound microenvironment. Targeting macrophages by manipulating or re-educating macrophages in inflammation using nanomedicines is a novel and feasible strategy for wound management. We discussed the design and physicochemical properties of nanomaterials and their functions for macrophages activation and anti-inflammatory signaling during wound therapy. The mechanism of action of the strategies and appropriate examples are also summarized to highlight the pros and cons of those approaches. Finally, the potential of nanomedicines to modulate macrophage polarization for skin regeneration is discussed.

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“…We also identified the key effector cell in Prostaglandin E2-induced activity of EPAC-1 (Exchange protein activated by cAMP 1) by targeting Prostaglandin E2 to different hepatic cell-types using different carriers and compare the effects [57]. In case of Kupffer cell targeting, it should be noted that delivery of large constructs to macrophages always confers the risk of direct activation of these cells by the carriers [52,58,59].…”

Section: Drug Targeting Approaches In Fibrotic Liversmentioning

confidence: 99%

Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation

Salvati

Poelstra

2022

Pharmaceutics

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Drug targeting and nanomedicine are different strategies for improving the delivery of drugs to their target. Several antibodies, immuno-drug conjugates and nanomedicines are already approved and used in clinics, demonstrating the potential of such approaches, including the recent examples of the DNA- and RNA-based vaccines against COVID-19 infections. Nevertheless, targeting remains a major challenge in drug delivery and different aspects of how these objects are processed at organism and cell level still remain unclear, hampering the further development of efficient targeted drugs. In this review, we compare properties and advantages of smaller targeted drug constructs on the one hand, and larger nanomedicines carrying higher drug payload on the other hand. With examples from ongoing research in our Department and experiences from drug delivery to liver fibrosis, we illustrate opportunities in drug targeting and nanomedicine and current challenges that the field needs to address in order to further improve their success.

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Amphiphilic galactomannan nanoparticles trigger the alternative activation of murine macrophages

Cited by 19 publications

References 65 publications

Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management

Nanomaterials targeting macrophages in sepsis: A promising approach for sepsis management

Recent advances in nanomedicines for regulation of macrophages in wound healing

Drug Targeting and Nanomedicine: Lessons Learned from Liver Targeting and Opportunities for Drug Innovation

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