Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis

Melo, Carolina Mirtes; Cardoso, Jéssica Ferreira; Perassoli, Fernanda Barçante; Neto, Ari Soares de Oliveira; Pinto, Luccas Moreira; Marques, Maria Betânia de Freitas; Mussel, Wagner da Nova; Magalhães, Juliana Teixeira de; Moura, Sandra Aparecida de Lima; Araújo, Marcelo Gonzaga de Freitas; Silva, Gisele Rodrigues Da

doi:10.1016/j.carbpol.2019.115608

Cited by 35 publications

(13 citation statements)

References 26 publications

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“…To improve the therapeutic effects of antifungal agents, PNs have been widely used in the treatment of candidiasis, including oral candidiasis [ 176 , 177 , 186 ] and vaginal candidiasis [ 178 , 179 , 180 , 181 , 182 ]. In the former, chitosan was incorporated into PNs, resulting in inhibition of the biofilm adhesion and formation of Candida .…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Gao

Liu

et al. 2021

IJMS

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Fungal infections have become a major health concern, given that invasive infections by Candida, Cryptococcus, and Aspergillus species have led to millions of mortalities. Conventional antifungal drugs including polyenes, echinocandins, azoles, allylamins, and antimetabolites have been used for decades, but their limitations include off-target toxicity, drug-resistance, poor water solubility, low bioavailability, and weak tissue penetration, which cannot be ignored. These drawbacks have led to the emergence of novel antifungal therapies. In this review, we discuss the nanosystems that are currently utilized for drug delivery and the application of antifungal therapies.

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%

Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Gao

Liu

et al. 2021

IJMS

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“…This accelerated elimination was due to the use of HA that was known as one of the major ligands of the CD44 receptor which was expressed on the vaginal epithelial cells, promoting the uptake of nanoparticles via receptor-mediated endocytosis and improving AMP bioavailability in the targeted area [76]. Moreover, adhesion of HA coated AMP EUD nanoparticles activated Toll-like receptors 2 and 4 that induced the release of various antimicrobial peptide and protective factors from the vaginal epithelium, facilitating the repair mechanism to preserve the epithelial barrier function which is important to prevent inflammation [77]. of the CD44 receptor which was expressed on the vaginal epithelial cells, promoting the uptake of nanoparticles via receptor-mediated endocytosis and improving AMP bioavailability in the targeted area [76].…”

Section: Nanocarriersmentioning

confidence: 99%

“…of the CD44 receptor which was expressed on the vaginal epithelial cells, promoting the uptake of nanoparticles via receptor-mediated endocytosis and improving AMP bioavailability in the targeted area [76]. Moreover, adhesion of HA coated AMP EUD nanoparticles activated Toll-like receptors 2 and 4 that induced the release of various antimicrobial peptide and protective factors from the vaginal epithelium, facilitating the repair mechanism to preserve the epithelial barrier function which is important to prevent inflammation [77]. .…”

Section: Nanocarriersmentioning

confidence: 99%

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Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

et al. 2020

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An optimal host–microbiota interaction in the human vagina governs the reproductive health status of a woman. The marked depletion in the beneficial Lactobacillus sp. increases the risk of infection with sexually transmitted pathogens, resulting in gynaecological issues. Vaginal infections that are becoming increasingly prevalent, especially among women of reproductive age, require an effective concentration of antimicrobial drugs at the infectious sites for complete disease eradication. Thus, topical treatment is recommended as it allows direct therapeutic action, reduced drug doses and side effects, and self-insertion. However, the alterations in the physiological conditions of the vagina affect the effectiveness of vaginal drug delivery considerably. Conventional vaginal dosage forms are often linked to low retention time in the vagina and discomfort which significantly reduces patient compliance. The lack of optimal prevention and treatment approaches have contributed to the unacceptably high rate of recurrence for vaginal diseases. To combat these limitations, several novel approaches including nano-systems, mucoadhesive polymeric systems, and stimuli-responsive systems have been developed in recent years. This review discusses and summarises the recent research progress of these novel approaches for vaginal drug delivery against various vaginal diseases. An overview of the concept and challenges of vaginal infections, anatomy and physiology of the vagina, and barriers to vaginal drug delivery are also addressed.

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“…This behavior suggested the use of HA nanocarriers for tumor targeting [4,5]. Recently, some authors suggested the interaction of HA with CD44 receptors as a mechanism of penetration of nanoparticles coated with HA, which was proposed to deliver amphotericin B to vaginal mucosa for vulvovaginal candidiasis [6]. The HA ability to interact with skin stratum corneum was studied to elucidate the mechanisms of the observed penetration enhancement properties.…”

Section: Introductionmentioning

confidence: 99%

Design of Experiments-Assisted Development of Clotrimazole-Loaded Ionic Polymeric Micelles Based on Hyaluronic Acid

et al. 2020

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Polymeric micelles based on amphiphilic polysaccharides have some advantages as a carrier of poorly soluble lipophilic drugs thanks to their characteristic "core–shell" structure. Previously, ionic polymeric micelles based on chitosan and fatty acids have been developed. The aim of the present study was the preparation and characterization of hyaluronic acid (HA) derivatives by direct ionic interaction between the HA carboxylic groups and the amine groups of dodecyl amine (DDA) and hexadecyl amine (HDA). The HA–HDA polymeric micelles were loaded with a poorly soluble hydrophobic antifungal drug, clotrimazole (CLO). A 23 full factorial experimental design was used to evaluate the effect of the following factors: HA/HDA ratio from 1:0.25 to 1:0.75, cholesterol (CHOL%) as percentage of HA from 10% to 30%, and preparation temperature from 20 to 40 °C. As dependent variables (responses), nanoparticle dimensions and clotrimazole concentration in the final colloidal dispersion were considered. To optimize the drug final concentration, the design was therefore expanded into a rotatable central composite design (CCD). The effects of the formulation variables and the composition of the optimized formulation were confirmed by a mixture design. Physicochemical characterization of the optimized formulation was performed, confirming the ionic interaction between the polysaccharide and the HDA.

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Amphotericin B-loaded Eudragit RL100 nanoparticles coated with hyaluronic acid for the treatment of vulvovaginal candidiasis

Cited by 35 publications

References 26 publications

Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Striking Back against Fungal Infections: The Utilization of Nanosystems for Antifungal Strategies

Promising Drug Delivery Approaches to Treat Microbial Infections in the Vagina: A Recent Update

Design of Experiments-Assisted Development of Clotrimazole-Loaded Ionic Polymeric Micelles Based on Hyaluronic Acid

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