2019
DOI: 10.1002/jor.24395
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Amplifying Bone Marrow Progenitors Expressing α‐Smooth Muscle Actin Produce Zonal Insertion Sites During Tendon‐to‐Bone Repair

Abstract: Traditional tendon‐to‐bone repair where the tendon is reattached to bone via suture anchors often results in disorganized scar production rather than the formation of a zonal insertion. In contrast, ligament reconstructions where tendon grafts are passed through bone tunnels can yield zonal tendon‐to‐bone attachments between the graft and adjacent bone. Therefore, ligament reconstructions can be used to study mechanisms that regulate zonal tendon‐to‐bone repair in the adult. Anterior cruciate ligament (ACL) re… Show more

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Cited by 17 publications
(39 citation statements)
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References 47 publications
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“…Our data suggest that implant surgery leads to Acta2.creERT2 expression in Pdgfra + and Ly6a + cells. Our findings are consistent with reports that performed Acta2 lineage tracing in other models of bone repair, such as endochondral fracture healing ( 10,15 ) and anterior cruciate ligament reconstruction; (41 ) these studies have shown that tamoxifen treatment at the time of bone injury results in the highest level of cre‐recombination as opposed to tamoxifen treatment at other time points. Thus, Acta2 expression is highly dynamic in healing bone tissue and is likely induced in PαS cells immediately after injury.…”
Section: Discussionsupporting
confidence: 92%
“…Our data suggest that implant surgery leads to Acta2.creERT2 expression in Pdgfra + and Ly6a + cells. Our findings are consistent with reports that performed Acta2 lineage tracing in other models of bone repair, such as endochondral fracture healing ( 10,15 ) and anterior cruciate ligament reconstruction; (41 ) these studies have shown that tamoxifen treatment at the time of bone injury results in the highest level of cre‐recombination as opposed to tamoxifen treatment at other time points. Thus, Acta2 expression is highly dynamic in healing bone tissue and is likely induced in PαS cells immediately after injury.…”
Section: Discussionsupporting
confidence: 92%
“…Finally, the radiographic‐based anterior drawer test was limited in that we did not control rotation of the femur during the test and viscoelastic properties could not be measured. However, our laboratory has recently developed an anterior−posterior drawer test on a mechanical testing machine, so viscoelastic properties can now be measured . Nevertheless, the radiographic method yielded percent changes in displacement that fell within previous reports for anterior drawer tests in ACL‐deficient human knees .…”
Section: Discussionsupporting
confidence: 67%
“…All mice were approved by the UConn Health Institutional Animal Care and Use Committee. Mice were anesthetized, sterilely prepped, and the surgery was conducted similarly to previous work . Three small incisions (3 mm each, spaced ∼30 mm apart) were made in the tail to access the tail tendons (Fig.…”
Section: Methodsmentioning
confidence: 99%
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“…A series of original research papers delves into tendon pathogenesis and healing, focusing on a broad range of topics: the effect of age and fatigue on tendon biomechanics, transcriptomics analysis of tendon healing, and treatment strategies that include hyaluronidase, pulsed electromagnetic fields, and parathyroid hormone . A collection of stem cell papers describes methods to generate and optimize stem cells and uses them to enhance tendon healing . In vitro models are used to examine how dexamethasone can protect the tendon from degeneration, the roles of substrate stiffness and pulsed electromagnetic fields in tendon responses to inflammation, and tendon responses to mechanical loading .…”
mentioning
confidence: 99%