Amputation Triggered by Gefitinib: An Unusual Clinical Presentation
Lihua Tao,
Jiaqi Ruan,
Xiaodong Chu
et al.
Abstract:Gefitinib is an epidermal growth factor tyrosine kinase inhibitor used as a targeted chemotherapeutic agent in the treatment of lung cancer and other solid malignancies. The most common adverse effects of gefitinib include dermatological side effects and gastrointestinal symptoms, with rare reports of vascular side effects such as myocardial infarction and stroke. We recently reported a case of a patient with diabetes and multiple comorbidities who developed a serious lower limb vascular adverse event after ge… Show more
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