Amputation Versus Limb‐Salvage Surgery in Patients with Osteosarcoma: A Meta‐analysis

Han, Gang; Bi, Wenzhi; Xu, Meng; Jia, Jun; Wang, Yan

doi:10.1007/s00268-016-3500-7

Cited by 103 publications

(85 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The preservation of the foot allows for a more functional gait and improved load bearing through the sole of the foot via an exoprosthesis. Although visually unusual, this procedure allows for a much more functional outcome compared to above the knee amputation . It is unknown if a similar procedure would be feasible for distal femoral osteosarcoma in dogs.…”

Section: Introductionmentioning

confidence: 99%

“…9 Rotationplasty is a limb salvage procedure performed in adolescent human patients with a primary tumor of the distal femur. [10][11][12][13] This procedure involves the en bloc resection of the distal femur and tibia, with preservation of the nerves, arterial, and venous supply to the distal extremity. The foot is then rotated 1808 and the tibia is fixed to the femur with a bone plate.…”

Section: Introductionmentioning

confidence: 99%

“…Although visually unusual, this procedure allows for a much more functional outcome compared to above the knee amputation. [10][11][12][13] It is unknown if a similar procedure would be feasible for distal femoral osteosarcoma in dogs.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Limb shortening as a strategy for limb sparing treatment of appendicular osteosarcoma of the distal radius in a dog

Boston

Skinner

2017

Veterinary Surgery

View full text Add to dashboard Cite

Objective: To develop and report a novel limb sparing technique for the distal radius in a dog. Study design: Case report.Animal: A 14-year-old, female spayed Labrador Retriever with an osteosarcoma of the right distal radius and a pathological fracture. A previous mast cell tumor had been treated 5 years prior to presentation with marginal excision and a full-course radiation over the right metacarpal bones. The dog had received 2 doses of palliative radiation just prior to presentation.Methods: A standard resection of the distal radius was used as a strategy to salvage the limb. Instead of replacing the 6-cm bone defect with an endoprosthesis, the limb was acutely shortened and a carpal arthrodesis plate was applied.Results: Postoperative function was good and limb shortening was well-tolerated. Radiographic evidence of early bone healing was noted at the osteotomy site. The dog experienced 3 postoperative complications: a focal area of skin necrosis managed successfully via surgical revision; infection resolving after long-term antibiotherapy; and a fracture of the third metacarpal bone through a screw hole, managed via screw removal and a custom external prosthesis. The patient was euthanatized due to presumptive chemotherapy complications 127 days after the procedure. Conclusion:Limb shortening limb salvage is technically feasible and can result in excellent limb use postoperatively, in spite of a significant loss in limb length.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Limb shortening as a strategy for limb sparing treatment of appendicular osteosarcoma of the distal radius in a dog

Boston

Skinner

2017

Veterinary Surgery

View full text Add to dashboard Cite

show abstract

“…With the combination of neoadjuvant chemotherapy and surgical resection, the 5‐year overall survival (OS) rate has increased to 60–70% . Currently, limb‐salvage surgery (LSS) is preferred over amputation for osteosarcoma treatment, as the two procedures show similar survival rates . More importantly, except for tumors of the tibia, LSS can result in better function and quality of life …”

mentioning

confidence: 99%

“…[3][4][5] Currently, limb-salvage surgery (LSS) is preferred over amputation for osteosarcoma treatment, as the two procedures show similar survival rates. [6][7][8] More importantly, except for tumors of the tibia, LSS can result in better function and quality of life. 9,10 According to the NCCN guidelines, 11 for osteosarcoma, wide margin excision should be achieved.…”

mentioning

confidence: 99%

Pre‐Operative chemotherapy response assessed by contrast‐enhanced MRI can predict the prognosis of Enneking surgical margins in patients with osteosarcoma

Qin

Bao

et al. 2018

Journal Orthopaedic Research

View full text Add to dashboard Cite

The method used to evaluate the response of osteosarcoma to preoperative chemotherapy before specimen resection is still unclear. The purpose of this study was to identify factors that contribute to overall survival (OS) and to discuss their roles in making a decision regarding Enneking surgical margins. Patients (109) with pathologically confirmed Enneking stage IIB osteosarcoma were retrospectively analyzed. Univariate and multivariate survival analyses were performed. Patient characteristics and chemotherapy‐induced contrast‐enhanced MRI changes were considered as potential factors. Changes in the tumor volume and the relative necrosis ratio measured by MRI were independent risk factors predicting the OS of patients who underwent limb‐salvage surgery. For those in whom the tumor volume had decreased (VolRatio <1) or the relative necrosis ratio had increased by at least 10% (NecRatioInc ≥0.1), there was no significant difference in OS between Enneking wide and marginal margins. Variables measured by contrast‐enhanced MRI could be used to evaluate chemotherapy response and increase the limb‐salvage rate. © 2018 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res

show abstract

Long noncoding RNA LINC01278 favors the progression of osteosarcoma via modulating miR‐133a‐3p/PTHR1 signaling

2020

Journal Cellular Physiology

View full text Add to dashboard Cite

As one of the most aggressive malignancies, osteosarcoma has high risks of death. Although long noncoding RNAs (lncRNAs) may promote the osteosarcoma progression as verified, the potential molecular mechanism of lncRNAs in osteosarcoma remains unknown. Herein, we analyzed lncRNA microarray of osteosarcoma and selected LINC01278 as the study object. Then, we found that the expression of LINC01278 tested by quantitative reverse‐transcription polymerase chain reaction was enhanced in tumor tissues compared with the para‐carcinoma tissues and related to clinical stage, distant metastasis in osteosarcoma. In addition, the clinical outcomes were poor in osteosarcoma patients with high LINC01278 level. Moreover, LINC01278 promoted proliferation and restrained apoptosis in osteosarcoma cells. Afterward, mechanistic studies turned out that LINC01278 was a competing endogenous RNA of parathyroid hormone type 1 receptor (PTHR1) in osteosarcoma by sponging miR‐133a‐3p, which was considered as a tumor inhibitor in osteosarcoma. Furthermore, PTHR1 downregulation restored the impacts of inhibited miR‐133a‐3p on the processes in osteosarcoma cells. Our findings clarified that the carcinogenic effect of LINC01278 in osteosarcoma was mediated through miR‐133a‐3p/PTHR1 signaling, creating a novel insight into good targets for the therapy and prognosis of osteosarcoma.

show abstract

Amputation Versus Limb‐Salvage Surgery in Patients with Osteosarcoma: A Meta‐analysis

Abstract: LSS results in higher 5-year survival rates and better functional outcomes as indicated by MSTS scores in patients with limb osteosarcomas.

Cited by 103 publications

References 54 publications

Limb shortening as a strategy for limb sparing treatment of appendicular osteosarcoma of the distal radius in a dog

Limb shortening as a strategy for limb sparing treatment of appendicular osteosarcoma of the distal radius in a dog

Pre‐Operative chemotherapy response assessed by contrast‐enhanced MRI can predict the prognosis of Enneking surgical margins in patients with osteosarcoma

Long noncoding RNA LINC01278 favors the progression of osteosarcoma via modulating miR‐133a‐3p/PTHR1 signaling

Contact Info

Product

Resources

About