Amrinone versus dopamine-nitroglycerin after reconstructive surgery for complete atrioventricular septal defect

Laitinen, Pirjo; Happonen, Juha‐Matti; Sairanen, Heikki; Peltola, Kaija; Rautiainen, Paula; Korpela, Reijo; Leijala, M.

doi:10.1016/s1053-0770(97)90123-3

Cited by 21 publications

(7 citation statements)

References 14 publications

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“…In addition, a short-acting vasodilator may be added, such as sodium nitroprusside or nitro-glycerin to recruit microcirculation (177–182) and reduce ventricular afterload resulting in better ventricular ejection and global CO, particularly when ventricular function is impaired. Orthogonal polarizing spectroscopy showed that addition of systemic IV nitroglycerin to dopamine/norepinephrine infusion restored tongue microvascular blood flow during adult septic shock (183).…”

Section: Resultsmentioning

confidence: 99%

Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine*

Brierley

Carcillo

Choong

et al. 2009

Critical Care Medicine

913

786

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Background The Institute of Medicine calls for the use of clinical guidelines and practice parameters to promote “best practices” and to improve patient outcomes. Objective 2007 update of the 2002 American College of Critical Care Medicine Clinical Guidelines for Hemodynamic Support of Neonates and Children with Septic Shock. Participants Society of Critical Care Medicine members with special interest in neonatal and pediatric septic shock were identified from general solicitation at the Society of Critical Care Medicine Educational and Scientific Symposia (2001–2006). Methods The Pubmed/MEDLINE literature database (1966–2006) was searched using the keywords and phrases: sepsis, septicemia, septic shock, endotoxemia, persistent pulmonary hypertension, nitric oxide, extracorporeal membrane oxygenation (ECMO), and American College of Critical Care Medicine guidelines. Best practice centers that reported best outcomes were identified and their practices examined as models of care. Using a modified Delphi method, 30 experts graded new literature. Over 30 additional experts then reviewed the updated recommendations. The document was subsequently modified until there was greater than 90% expert consensus. Results The 2002 guidelines were widely disseminated, translated into Spanish and Portuguese, and incorporated into Society of Critical Care Medicine and AHA sanctioned recommendations. Centers that implemented the 2002 guidelines reported best practice outcomes (hospital mortality 1%–3% in previously healthy, and 7%– 10% in chronically ill children). Early use of 2002 guidelines was associated with improved outcome in the community hospital emergency department (number needed to treat = 3.3) and tertiary pediatric intensive care setting (number needed to treat = 3.6); every hour that went by without guideline adherence was associated with a 1.4-fold increased mortality risk. The updated 2007 guidelines continue to recognize an increased likelihood that children with septic shock, compared with adults, require 1) proportionally larger quantities of fluid, 2) inotrope and vasodilator therapies, 3) hydrocortisone for absolute adrenal insufficiency, and 4) ECMO for refractory shock. The major new recommendation in the 2007 update is earlier use of inotrope support through peripheral access until central access is attained. Conclusion The 2007 update continues to emphasize early use of age-specific therapies to attain time-sensitive goals, specifically recommending 1) first hour fluid resuscitation and inotrope therapy directed to goals of threshold heart rates, normal blood pressure, and capillary refill ≤2 secs, and 2) subsequent intensive care unit hemodynamic support directed to goals of central venous oxygen saturation >70% and cardiac index 3.3–6.0 L/min/m2.

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Section: Resultsmentioning

confidence: 99%

Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine*

Brierley

Carcillo

Choong

et al. 2009

Critical Care Medicine

913

786

View full text Add to dashboard Cite

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“…Duration of MV or LOS (PICU and/or hospital) was reported by 10 of the 16 studies. 2,13,14,16 –18,20 –23 Only in one report the duration of MV was positively influenced, by a combination of milrinone and inhaled nitric oxide (iNO) in children following the Fontan operation. 21 In the other nine studies, no positive effect of inotropes was found on important outcome measures such as duration of MV and LOS.…”

Section: Resultsmentioning

confidence: 99%

“…Amrinone, a phosphodiesterase inhibitor, is not being used anymore but has been shown to increase cardiac output in children following heart surgery. 9,13,14 Postoperative Temperature Control…”

Section: The Ideal Inotropementioning

confidence: 99%

The Perspective of the Intensivist on Inotropes and Postoperative Care Following Pediatric Heart Surgery: An International Survey and Systematic Review of the Literature

Roeleveld

Klerk

2017

World J Pediatr Congenit Heart Surg

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Introduction:Inotropes are frequently being used in children undergoing heart surgery to prevent or treat low cardiac output syndrome (LCOS). There is only limited evidence that inotropes actually positively influence postoperative outcome. Our aim was to describe the current international practice variation in the use of inotropes following congenital heart surgery.Methods:We developed an online survey regarding the postoperative use of inotropes. We sent an invitation to all 197 registered members of the Pediatric Cardiac Intensive Care Society (PCICS) to participate in the survey. We also performed a systematic review of the literature.Results:Ninety-eight people (50%) responded, representing 62 international centers. Milrinone is routinely used perioperatively by 90 respondents (97%). Adrenaline/epinephrine is routinely used by 43%, dopamine by 36%, dobutamine by 11%, and levosimendan by 6%. Steroids are used routinely by 54% before initiating cardiopulmonary bypass. Vasopressin is used by 44% of respondents. The development of LCOS is monitored with lactate in 99% of respondents, physical examination (98%), intermittent mixed venous saturation (76%), continuous mixed venous saturation (13%), echocardiography (53%), core–peripheral temperature gap (29%), near-infrared spectrometry (25%), and 4% use cardiac output monitors (PiCCO, USCOM). To improve cardiac output, 42% add/increase milrinone, 37% add adrenaline, and 15% add dopamine. Rescue therapy is titrated individually, based on the patients’ pathophysiology. A systematic review of the literature failed to show compelling evidence with regard to the benefit of inotropes.Conclusions:Despite the lack of sufficient evidence, milrinone is used by the vast majority of caregivers following congenital heart surgery.

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“…In addition, a short-acting vasodilator may be added, such as sodium nitroprusside or nitroglycerin to recruit microcirculation. [215][216][217][218][219][220][221] Orthogonal polarizing spectroscopy showed that addition of systemic IV nitroglycerin to dopamine/norpeinephrine infusion restored tongue microvascular blood flow during adult septic shock. 221 Nitrovasodilators can be titrated to the desired effect, but use of nitroprusside is limited if there is reduced renal function secondary to the accumulation of sodium thiocyanate.…”

Section: Vasodilatorsmentioning

confidence: 99%

American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock: Erratum

2017

Critical Care Medicine

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Amrinone versus dopamine-nitroglycerin after reconstructive surgery for complete atrioventricular septal defect

Cited by 21 publications

References 14 publications

Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine*

Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine*

The Perspective of the Intensivist on Inotropes and Postoperative Care Following Pediatric Heart Surgery: An International Survey and Systematic Review of the Literature

American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock: Erratum

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