Amyand appendicitis

Szczepanski, Jason; White, Roland Z; Au, John

doi:10.1016/j.surg.2022.02.013

Cited by 1 publication

(1 citation statement)

References 3 publications

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“…Various factors may influence the incidence of appendicitis in different regions, including dietary habits, lifestyle, environmental factors, and genetics. [4] Diagnosis of appendicitis typically involves physical examination, symptom inquiry, blood tests, and imaging studies. [5] Upon confirmation of diagnosis, surgical treatment is usually undertaken.…”

Section: Introductionmentioning

confidence: 99%

Mining and exploration of appendicitis nursing targets: An observational study

Mi,

Kang,

Hou

et al. 2024

Medicine

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Appendicitis is an inflammation caused by obstruction of the appendiceal lumen or termination of blood supply leading to appendiceal necrosis followed by secondary bacterial infection. The relationship between TYROBP gene and the nursing of appendicitis remains unclear. The appendicitis dataset GSE9579 profile was downloaded from the gene expression omnibus database generated from GPL571. Differentially expressed genes were screened, followed by weighted gene co-expression network analysis, functional enrichment analysis, gene set enrichment analysis, construction and analysis of protein–protein interaction network, Comparative Toxicogenomics Database analysis, and immune infiltration analysis. Heatmaps of gene expression levels were plotted. A total of 1570 differentially expressed genes were identified. According to gene ontology analysis, they were mainly enriched in organic acid metabolic process, condensed chromosome kinetochore, oxidoreductase activity. In Kyoto Encyclopedia of Gene and Genome analysis, they mainly concentrated in metabolic pathways, P53 signaling pathway, PPAR signaling pathway. The soft threshold power in weighted gene co-expression network analysis was set to 12. Through the construction and analysis of protein–protein interaction network, 5 core genes (FCGR2A, IL1B, ITGAM, TLR2, TYROBP) were obtained. Heatmap of core gene expression levels revealed high expression of TYROBP in appendicitis samples. Comparative Toxicogenomics Database analysis found that core genes (FCGR2A, IL1B, ITGAM, TLR2, TYROBP) were closely related to abdominal pain, gastrointestinal dysfunction, fever, and inflammation occurrence. TYROBP gene is highly expressed in appendicitis, and higher expression of TYROBP gene indicates worse prognosis. TYROBP may serve as a molecular target for appendicitis and its nursing.

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Section: Introductionmentioning

confidence: 99%