Amygdala circuit transitions supporting developmentally-appropriate social behavior

Multiple routes of communication within the amygdala-mPFC network: A comparative approach in humans and macaques

“…We mainly focused the scope of the review in the adult brain, not taking into account several factors that might also affect the anatomical and functional interplay within AMG-mPFC circuits such as sex, age or personality traits (see for instance Tottenham, 2015 ; Reber and Tranel, 2017 ; Kenwood and Kalin, 2021 ; Ferrara and Opendak, 2023 ). Another limitation of our hypotheses is that evidences come from different species (humans vs macaques) and from different approaches with different spatial scales: a microscopic scale providing structural connectivity of each AMG nuclei in macaques versus a macroscopic scale in humans using rs-fMRI or DWI.…”

Synaptic pruning during adolescence shapes adult social behavior in both males and females

“…Another possible limitation of our study is that although NIF was infused specifically in the NAc, we could not control if NIF diffused to neighboring areas. Thus, the changes in social behavior we found could result from a combined effect of NIF on NAc and neighboring areas associated with social processes (e.g., amygdala, hypothalamus) (Ferrara & Opendak, 2023; Gomez‐Gomez et al., 2019; Hu et al., 2021; Lischinsky et al., 2023). Additionally, the vast connectivity of the NAc may have produced downstream effects on brain regions innervated by the NAc, and further studies will be necessary to address this possibility.…”