Amygdala GABA Neurons Project To vlPAG And mPFC

Sun, Yuanyuan; Blanco-Centurión, Carlos; Zou, Bingyu; Bendell, Emmaline; Shiromani, Priyattam J.; Li, Meng

doi:10.1016/j.ibror.2019.03.001

Cited by 21 publications

(8 citation statements)

References 20 publications

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“…Particularly, when GABAergic inhibition occurs in motoneurons, muscle weakness, or even paralysis may arise. Interestingly, our group recently identified a group of GABAergic bifurcating neurons in CeA and the basolateral amygdala (BLA) that simultaneously project to the medial prefrontal cortex (mPFC) and the vlPAG (Sun et al, 2019). Because vlPAG is a critical hub for controlling muscle tone (Weber et al, 2018), excessive GABAergic input to the vlPAG may lead to reduced motor output.…”

Section: Discussionmentioning

confidence: 99%

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

Sun

Blanco-Centurión

Bendell

et al. 2019

eLife

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Recent studies showed activation of the GABAergic neurons in the central nucleus of the amygdala (CeA) triggered cataplexy of sleep disorder narcolepsy. However, there is still no direct evidence on CeA GABAergic neurons’ real-time dynamic during cataplexy. We used a deep brain calcium imaging tool to image the intrinsic calcium transient as a marker of neuronal activity changes in the narcoleptic VGAT-Cre mice by expressing the calcium sensor GCaMP6 into genetically defined CeA GABAergic neurons. Two distinct GABAergic neuronal groups involved in cataplexy were identified: spontaneous cataplexy-ON and predator odor-induced cataplexy-ON neurons. Majority in the latter group were inactive during regular sleep/wake cycles but were specifically activated by predator odor and continued their intense activities into succeeding cataplexy bouts. Furthermore, we found that CeA GABAergic neurons became highly synchronized during predator odor-induced cataplexy. We suggest that the abnormal activation and synchronization of CeA GABAergic neurons may trigger emotion-induced cataplexy.

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Section: Discussionmentioning

confidence: 99%

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

Sun

Blanco-Centurión

Bendell

et al. 2019

eLife

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“…For example, the central nucleus of the amygdala (CeA) is a striatal-like GABAergic structure that projects to the hypothalamus and brainstem to initiate fear responses ( Pare and Duvarci, 2012 ). Recent viral tracing work suggests that single neurons in the CeA send bifurcating projections to the medial prefrontal cortex (mPFC) and the ventrolateral periaqueductal gray ( Sun Y. et al, 2019 ) to potentially dually regulate adaptive emotional responses. Interestingly, such GABAergic projections were also found to originate from the basolateral amygdala (BLA), a region thought to be cortical-like and predominately populated by glutamatergic neurons.…”

Section: Subcortical Long-range Gabaergic Neuronsmentioning

confidence: 99%

Long-Range GABAergic Projections of Cortical Origin in Brain Function

Urrutia-Piñones

Morales-Moraga

Sanguinetti-González

et al. 2022

Front. Syst. Neurosci.

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The study of long-range GABAergic projections has traditionally been focused on those with subcortical origin. In the last few years, cortical GABAergic neurons have been shown to not only mediate local inhibition, but also extend long-range axons to remote cortical and subcortical areas. In this review, we delineate the different types of long-range GABAergic neurons (LRGNs) that have been reported to arise from the hippocampus and neocortex, paying attention to the anatomical and functional circuits they form to understand their role in behavior. Although cortical LRGNs are similar to their interneuron and subcortical counterparts, they comprise distinct populations that show specific patterns of cortico-cortical and cortico-fugal connectivity. Functionally, cortical LRGNs likely induce timed disinhibition in target regions to synchronize network activity. Thus, LRGNs are emerging as a new element of cortical output, acting in concert with long-range excitatory projections to shape brain function in health and disease.

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“…Another is the connection between the central medial nucleus of the thalamus, which when lesioned temporarily alleviates mechanical hyperalgesia in a neuropathic pain model (Sun et al, 2020 ). Additional examples of reciprocal connections between the vlPAG and other brain regions, such as the amygdala (Ottersen, 1981 ; Hasue and Shammah-Lagnado, 2002 ; Oka et al, 2008 ; Sun et al, 2019 ), show pain-induced alterations (Li and Sheets, 2018 ). Multi-region circuits, such as that between the vlPAG, central medial thalamic nucleus, and the BLA are activated by neuropathic pain (Sun et al, 2020 ), which is known to project back to the vlPAG via neurons with distinct intrinsic membrane properties within the central medial and lateral nuclei of the amygdala (Rizvi et al, 1991 ; Li and Sheets, 2018 ).…”

Section: Circuit Diversitymentioning

confidence: 99%

Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway

McPherson

Ingram

2022

Front. Syst. Neurosci.

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The descending pain modulatory pathway exerts important bidirectional control of nociceptive inputs to dampen and/or facilitate the perception of pain. The ventrolateral periaqueductal gray (vlPAG) integrates inputs from many regions associated with the processing of nociceptive, cognitive, and affective components of pain perception, and is a key brain area for opioid action. Opioid receptors are expressed on a subset of vlPAG neurons, as well as on both GABAergic and glutamatergic presynaptic terminals that impinge on vlPAG neurons. Microinjection of opioids into the vlPAG produces analgesia and microinjection of the opioid receptor antagonist naloxone blocks stimulation-mediated analgesia, highlighting the role of endogenous opioid release within this region in the modulation of nociception. Endogenous opioid effects within the vlPAG are complex and likely dependent on specific neuronal circuits activated by acute and chronic pain stimuli. This review is focused on the cellular heterogeneity within vlPAG circuits and highlights gaps in our understanding of endogenous opioid regulation of the descending pain modulatory circuits.

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Amygdala GABA Neurons Project To vlPAG And mPFC

Abstract: Highlights Single amygdala GABA neuron projects to both brain stem and cortex. Bifurcating amygdala neurons may regulate emotions and muscle tone.

Cited by 21 publications

References 20 publications

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

Activity dynamics of amygdala GABAergic neurons during cataplexy of narcolepsy

Long-Range GABAergic Projections of Cortical Origin in Brain Function

Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway

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