Amygdala-prefrontal cortex white matter tracts are widespread, variable and implicated in amygdala modulation in adolescents

Goetschius, Leigh G.; Hein, Tyler C.; Mattson, Whitney I.; Lopez-Duran, Nestor L.; Dotterer, Hailey L.; Welsh, Robert C.; Mitchell, Colter; Hyde, Luke W.; Monk, Christopher S.

doi:10.1016/j.neuroimage.2019.02.009

Cited by 37 publications

(49 citation statements)

References 67 publications

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“…Probabilistic tractography uses dMRI to precisely map white matter tracts between structures ( Behrens et al, 2007 ). This method, in a smaller subset of the current sample, showed that amygdala white matter connectivity with the orbitofrontal cortex (OFC – Brodmann’s Area (BA) 47, 11), dorsomedial PFC (BA10), and subgenual cingulate (BA25) was greater than amygdala white matter connectivity with other PFC regions, such as the dorsal anterior cingulate and dorsolateral PFC ( Goetschius et al, 2019 ). Non-human primate studies also provide support for specific amygdala connectivity with the OFC, dmPFC, and subgenual cingulate ( Ray and Zald, 2012 ; Zikopoulos et al, 2017 ).…”

Section: Introductionmentioning

confidence: 90%

“…Non-human primate studies also provide support for specific amygdala connectivity with the OFC, dmPFC, and subgenual cingulate ( Ray and Zald, 2012 ; Zikopoulos et al, 2017 ). Additionally, our previous work revealed that adolescents with less white matter connectivity between the amygdala and the OFC (right BA47, left BA11) and dmPFC (bilateral BA10), but not the dorsolateral PFC, anterior cingulate, or subgenual cingulate, showed greater amygdala activation to threatening faces ( Goetschius et al, 2019 ). Thus, the OFC, dmPFC, and subgenual cingulate seem to be well-connected via white matter to the amygdala.…”

Section: Introductionmentioning

confidence: 99%

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WITHDRAWN:Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity

Goetschius

Hein

Mitchell

et al. 2020

Developmental Cognitive Neuroscience

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Childhood adversity is heterogeneous with potentially distinct dimensions of violence exposure and social deprivation. These dimensions may differentially shape emotion-based neural circuitry, such as amygdala–prefrontal cortex (PFC) white matter connectivity. Amygdala–orbitofrontal cortex (OFC) white matter connectivity has been linked to regulation of the amygdala’s response to emotional stimuli. Using a preregistered analysis plan, we prospectively examined the effects of childhood exposure to two dimensions of adversity, violence exposure and social deprivation, on the adolescent amygdala–PFC white matter connectivity. We also reproduced the negative correlation between amygdala–PFC white matter connectivity and amygdala activation to threat faces. 183 15–17-year-olds were recruited from the Fragile Families and Child Wellbeing Study — a longitudinal, birth cohort, sample of predominantly low-income youth. Probabilistic tractography revealed that childhood violence exposure and social deprivation interacted to predict the probability of adolescent right hemisphere amygdala–OFC white matter connectivity. High violence exposure with high social deprivation related to less amygdala–OFC white matter connectivity. Violence exposure was not associated with white matter connectivity when social deprivation was at mean or low levels (i.e., relatively socially supportive contexts). Therefore, social deprivation may exacerbate the effects of childhood violence exposure on the development of white matter connections involved in emotion processing and regulation. Conversely, social support may buffer against them.

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Section: Introductionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

WITHDRAWN:Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity

Goetschius

Hein

Mitchell

et al. 2020

Developmental Cognitive Neuroscience

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“…The amygdala and PFC are connected both structurally and functionally 42,47‐51 and the amygdala has an inhibitory effect and can deactivate mPFC activity 42,47,52 . The reduction in connectivity between the right amygdala and DLPFC can point to a decrease in the inhibitory effect of the amygdala on the PFC that was related to the greater CBT effect.…”

Section: Discussionmentioning

confidence: 99%

Alterations in Brain Function After Cognitive Behavioral Therapy for Migraine in Children and Adolescents

et al. 2020

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Objectives.-This basic mechanistic study examined the changes in brain activation and resting-state connectivity after 8 weeks of CBT in youth with migraine.Background.-Cognitive behavioral therapy (CBT) is a psychological intervention that is effective in reducing pain in migraine patients. However, the neural mechanisms underlying CBT in adolescents with migraine are not yet known.Methods.-Eighteen adolescents with migraine (15 females, age 15.1 ± 2.1 years [mean ± SD]) completed 8 weekly CBT sessions. Before the first and after the final CBT session, participants underwent structural and resting-state blood-oxygen-leveldependent contrast MRI scans. Arterial spin labeling was also used to examine brain activation during the resting state. For connectivity analyses, the right and left amygdala were chosen as seed regions. Relationships of the time courses within these seeds with voxels across the whole brain were evaluated.Results.-Headache frequency decreased from 15 ± 7.4 headaches per month before CBT to 10 ± 7.4 after CBT (P < .001). After CBT, greater brain activations in frontal regions involved in cognitive regulation of pain were found. In addition, after CBT increased connectivity between the amygdala and frontal regions was observed. Associations between brain activation and amygdalar connectivity with a reduction in headache frequency were also observed.Conclusions.-Alterations in brain function and amygdalar connectivity with areas involved in nociceptive processing, cognitive function, and emotional regulation may underlie the ability of CBT to aid in the prevention of headaches in migraine patients.

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“…The first principle requires a much closer alignment between human and animal research. There is a plethora of human literature on functional and structural connectivity in disordered affect (109)(110)(111)(112)(113)(114). These human neural pathways should serve as a blueprint for rodent experimentation, yet most circuit studies to-date base their hypotheses on prior rodent work.…”

Section: Sex As a Biological Variablementioning

confidence: 99%

MouseCircuits.org: An online repository to guide the circuit era of disordered affect

Anderson¹,

Dumitriu²

2020

Preprint

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Affective disorders rank amongst the most disruptive and prevalent psychiatric diseases, resulting in enormous societal and economic burden, and immeasurable personal costs. Novel therapies are urgently needed but have remained elusive. The era of circuit-mapping in rodent models of disordered affect, ushered in by recent technological advancements allowing for precise and specific neural control, has reenergized the hope for precision psychiatry. Here, we present a novel whole-brain cumulative network and critically access the progress made todate on circuits mediating affective-like behaviors in rodents to seek unifying principles of this cumulative data. We identified 106 original manuscripts in which optogenetics or chemogenetics were used to dissect behaviors related to fear-like, depressive-like or anxiety-like behaviors in rodents. Focusing on the 60 manuscripts that investigated pathways rather than regions, we identified emergent themes. We found that while a few pathways have been validated across similar behaviors and multiple labs, the data is mostly disjointed, with evidence of bidirectional effects of several pathways. Additionally, there is a need for analysis informed by observation prior to perturbation. Given the complex nature of brain connectivity, we argue that the compartmentalized viewpoint that develops as a consequence of fragmented pathway-specific manipulations does not readily lend itself to an integrative picture. To address this, we launched an interactive online consortium, MouseCircuits.org, an open-source platform for consolidated circuit data. This tool aims to support the shared vision of informed circuit dissection that ultimately leads to prevention and treatment of human disorders.

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Amygdala-prefrontal cortex white matter tracts are widespread, variable and implicated in amygdala modulation in adolescents

Cited by 37 publications

References 67 publications

WITHDRAWN:Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity

WITHDRAWN:Childhood violence exposure and social deprivation predict adolescent amygdala-orbitofrontal cortex white matter connectivity

Alterations in Brain Function After Cognitive Behavioral Therapy for Migraine in Children and Adolescents

MouseCircuits.org: An online repository to guide the circuit era of disordered affect

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