An 8‐year longitudinal study of muscle strength, muscle fiber size, and dynamic electromyogram in individuals with late polio

Grimby, Gunnar; Stålberg, Erik; Sandberg, Andreas; Sunnerhagen, Katharina S.

doi:10.1002/(sici)1097-4598(199811)21:11<1428::aid-mus10>3.3.co;2-d

Cited by 36 publications

(52 citation statements)

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“…Thus, ultrasound reflected the expected changes based on known pathological changes in PPS. 6,[8][9][10] The differences between PPS and healthy controls serve as a proof of principle; ultrasound was sufficiently sensitive to distinguish between muscles affected by PPS and healthy muscles.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6][7] There is often extensive fibrosis and steatosis of muscle fibers, which disrupts the normal muscle architecture. 6,[8][9][10] Any skeletal muscle can be involved, and the severity of involvement is highly variable. Clinical involvement and disease progression in PPS are usually assessed with functional tests, such as muscle strength measurements.…”

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confidence: 99%

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Quantitative muscle ultrasound and quadriceps strength in patients with post‐polio syndrome

et al. 2014

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Quantitative muscle ultrasound and quadriceps strength in patients with post‐polio syndrome

et al. 2014

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“…The subjects included in this study were 43 polio survivors (polio group) and 20 healthy controls (control group). The polio group was selected from 110 registered polio survivors who had joined the annual free health examination organized by the local polio patient association and our department based on the following inclusion criteria: (1) a previous history of polio infection diagnosed at a hospital or an official certificate of physical disability induced by polio; (2) between age 50 and 80 years; (3) no musculoskeletal diseases that damage the spinal cord or peripheral nerves; (4) no neurological diseases except polio; and (5) no metabolic diseases that would affect the peripheral nervous system. The polio group consisted of 25 men [age 58.4 6 5.1 years, height 164.8 6 8.1 cm (mean 6 SD)] and 18 women (age 60.8 6 6.1 years, height 152.3 6 7.8 cm) who had contracted the disease in early childhood, 20 of whom were diagnosed with PPS based on previously reported criteria.…”

Section: Subjectsmentioning

confidence: 99%

Repeater F‐waves are signs of motor unit pathology in polio survivors

et al. 2015

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Introduction The purpose of this study was to determine whether F‐waves reveal electrophysiological features of anterior horn cells in polio survivors. Methods Forty‐three polio survivors and 20 healthy controls underwent motor nerve conduction studies of the median and tibial nerves bilaterally, including sampling of F‐waves elicited by 100 stimuli and the determination of motor unit number estimation (MUNE). Results A significant increase in abnormally stereotyped (“repeater”) F–waves and a reduction of F‐wave persistence were observed in both nerves in the polio group as compared with the control group. Repeater F‐waves had a negative correlation with MUNE. Conclusions These trends in F‐wave persistence and repeater F‐waves after motor unit loss are characteristic findings in polio survivors. Repeater F‐waves are a sign of motor unit pathology. Muscle Nerve 51 :680–685, 2015

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“…In longitudinal studies with macro EMG, a continuous loss of neurons is demonstrated with exaggerated speed compared with normal age-dependent degeneration [25]. New weakness appears when the compensatory mechanisms are no longer sufficient, and occurs when Macro MUP exceeds 20 times normal size [25].…”

Section: Role Of Clinical Neurophysiologymentioning

confidence: 99%

EFNS guideline on diagnosis and management of post‐polio syndrome. Report of an EFNS task force

Farbu

Gilhus

Barnes

et al. 2006

Euro J of Neurology

157

113

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Post‐polio syndrome (PPS) is characterized by new or increased muscular weakness, atrophy, muscle pain and fatigue several years after acute polio. The aim of the article is to prepare diagnostic criteria for PPS, and to evaluate the existing evidence for therapeutic interventions. The Medline, EMBASE and ISI databases were searched. Consensus in the group was reached after discussion by e‐mail. We recommend Halstead's definition of PPS from 1991 as diagnostic criteria. Supervised, aerobic muscular training, both isokinetic and isometric, is a safe and effective way to prevent further decline for patients with moderate weakness (Level B). Muscular training can also improve muscular fatigue, muscle weakness and pain. Training in a warm climate and non‐swimming water exercises are particularly useful (Level B). Respiratory muscle training can improve pulmonary function. Recognition of respiratory impairment and early introduction of non‐invasive ventilatory aids prevent or delay further respiratory decline and the need for invasive respiratory aid (Level C). Group training, regular follow‐up and patient education are useful for the patients’ mental status and well‐being. Weight loss, adjustment and introduction of properly fitted assistive devices should be considered (good practice points). A small number of controlled studies of potential‐specific treatments for PPS have been completed, but no definitive therapeutic effect has been reported for the agents evaluated (pyridostigmine, corticosteroids, amantadine). Future randomized trials should particularly address the treatment of pain, which is commonly reported by PPS patients. There is also a need for studies evaluating the long‐term effects of muscular training.

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An 8‐year longitudinal study of muscle strength, muscle fiber size, and dynamic electromyogram in individuals with late polio

Cited by 36 publications

References 0 publications

Quantitative muscle ultrasound and quadriceps strength in patients with post‐polio syndrome

Quantitative muscle ultrasound and quadriceps strength in patients with post‐polio syndrome

Repeater F‐waves are signs of motor unit pathology in polio survivors

EFNS guideline on diagnosis and management of post‐polio syndrome. Report of an EFNS task force

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