An Absorption Assessment of Eggshell Calcium Citrate Treated by PEF in Mice

Song, Ligang; Shen, Tong; Ye, Hai Qing

doi:10.4028/www.scientific.net/amr.634-638.1413

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…Moreover, the citrate ions, which can be released from CCT, are conducive to the formation of hydroxyapatite (HA) in vivo [18][19][20]. Furthermore, a previous study with Japanese white rabbits concluded that CCT could positively stimulate fracture healing in the early stages when defects were not yet too severe [21,22]. Thus, the combination of both CSD and CCT is an effective strategy for developing bone repair materials with good therapeutic properties.…”

Section: Introductionmentioning

confidence: 99%

Effects of ATP on the Physicochemical Properties and Cytocompatibility of Calcium Sulfate/Calcium Citrate Composite Cement

et al. 2023

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Adenosine triphosphate (ATP), acting as a source of energy, has effects on cellular activities, such as adhesion, proliferation, and differentiation. In this study, ATP-loaded calcium sulfate hemihydrate/calcium citrate tetrahydrate cement (ATP/CSH/CCT) was successfully prepared for the first time. The effect of different contents of ATP on the structure and physicochemical properties of ATP/CSH/CCT was also studied in detail. The results indicated that incorporating ATP into the cement did not significantly alter their structures. However, the addition ratio of ATP directly impacted the mechanical properties and in vitro degradation properties of the composite bone cement. The compressive strength of ATP/CSH/CCT gradually decreased with an increasing ATP content. The degradation rate of ATP/CSH/CCT did not significantly change at low concentrations of ATP, but it increased with a higher ATP content. The composite cement induced the deposition of a Ca-P layer in a phosphate buffer solution (PBS, pH = 7.4). Additionally, the release of ATP from the composite cement was controlled. The ATP was controlled releasing at the 0.5% and 1% ATP in cement by the diffusion of ATP and the degradation of the cement, whereas it was controlled by the diffusion process merely at the 0.1% ATP in cement. Furthermore, ATP/CSH/CCT demonstrated good cytoactivity with the addition of ATP and is expected to be used for the repair and regeneration of bone tissue.

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Section: Introductionmentioning

confidence: 99%

Effects of ATP on the Physicochemical Properties and Cytocompatibility of Calcium Sulfate/Calcium Citrate Composite Cement

et al. 2023

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“…Furthermore, a previous study with Japanese white rabbits concluded that it could positively stimulate fracture healing in early stages when defects are not yet too severe. 4,5 Additionally, Wei et al 6 demonstrated that combined with recombinant human bone morphogenetic protein-2 (rhBMP-2), it obviously enhanced bone regeneration in bone defects. However, the main drawbacks associated with it include poor formability and washout resistance.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D3-loaded calcium citrate/calcium sulfate composite cement with enhanced physicochemical properties, drug release, and cytocompatibility

Chen

Ding

et al. 2020

J Biomater Appl

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Vitamin D3 (VD3), an important regulator of calcium and phosphate ion concentrations in blood serum, participates in bone formation by promoting calcium and citrate deposition at defect sites while further stimulating bone calcification and osteoblast function. In this study, VD3-loaded calcium sulfate (VD3/CS) and calcium citrate/calcium sulfate (VD3/ CC/CS) cements were successfully fabricated for the first time. The incorporation of VD3 into the cements did not alter their structures or physicochemical properties. Additionally, compared with the VD3/CS cement, the VD3/CC/CS composite cement showed higher mechanical strength (28.87 MPa), better injectability (94.48%), and more appropriate setting time (23.7 min). Depending on the method by which the loaded VD3 was adsorbed, both VD3/CS and VD3/CC/ CS cements could achieve sustained drug release. However, due to their different compositions, VD3/CS cement samples, owing to the dissolution of their matrix, showed faster VD3 release rates, while VD3/CC/CS composite cement samples showed more controlled VD3 release rates, owing to the presence of a physical barrier created by calcium citrate. The VD3/CC/CS composite cement samples also demonstrated excellent bioactivity at cellular level, indicating that the VD3/CC/CS composite cement might be beneficial for the localised treatment of bone defects, especially osteoporotic bone.

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Assessment the levels of tartrate-resistant acid phosphatase (TRAP) on mice fed with eggshell calcium citrate malate

Zhang

Lin

et al. 2013

International Journal of Biological Macromolecules

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An Absorption Assessment of Eggshell Calcium Citrate Treated by PEF in Mice

Cited by 6 publications

References 24 publications

Effects of ATP on the Physicochemical Properties and Cytocompatibility of Calcium Sulfate/Calcium Citrate Composite Cement

Effects of ATP on the Physicochemical Properties and Cytocompatibility of Calcium Sulfate/Calcium Citrate Composite Cement

Vitamin D3-loaded calcium citrate/calcium sulfate composite cement with enhanced physicochemical properties, drug release, and cytocompatibility

Assessment the levels of tartrate-resistant acid phosphatase (TRAP) on mice fed with eggshell calcium citrate malate

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