An abundantly secreted glycoprotein from Drosophila melanogaster is related to mammalian secretory proteins produced in rheumatoid tissues and by activated macrophages

Kirkpatrick, Robert B.; Matico, Rosalie; McNulty, Dean E.; Strickler, J. Rudi; Rosenberg, Martin

doi:10.1016/0378-1119(94)00756-i

Cited by 87 publications

(76 citation statements)

References 16 publications

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“…This is in agreement with the identification of DS47, a likely member of the IDGF family, in culture supernatants of S2, also an embryo-derived cell line (3). We have purified IDGF-2 from * This work was supported by National Institutes of Health Grant AI36900 (to R. A. M.) and a grant from the Spanish Agency for International Cooperation (AECI) (to J. T. and A. S. L.) The costs of publication of this article were defrayed in part by the payment of page charges.…”

supporting

confidence: 91%

Crystal Structure of Imaginal Disc Growth Factor-2

Varela

Llera

Mariuzza

et al. 2002

Journal of Biological Chemistry

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supporting

confidence: 91%

Crystal Structure of Imaginal Disc Growth Factor-2

Varela

Llera

Mariuzza

et al. 2002

Journal of Biological Chemistry

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“…YKL-40, after inducing the maturation of monocytes to macrophages, is secreted by macrophages during the late stages of differentiation and eventually by the activated macrophages (5,(12)(13)(14)(15). Clinical studies revealed elevated YKL-40 levels particularly in diseases characterized with inflammation, extra-cellular remodeling and ongoing fibrosis (11).…”

Section: Discussionmentioning

confidence: 99%

“…YKL-40 is closely related to both early and late phases of the atherosclerotic process. YKL-40 promotes maturation of monocytes to macrophages; afterwards YKL-40 gets secreted by macrophages during the late stages of differentiation and eventually by the activated macrophages (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Increased YKL-40 levels in patients with isolated coronary artery ectasia: an observational study

Kocaman¹,

Çetin²,

Durakoğlugil³

et al. 2013

Anadolu Kardiyol Derg

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Objective: YKL-40, a new biomarker of localized inflammation, is secreted by macrophages within the atherosclerotic plaques. Coronary artery ectasia (CAE) is a clinical entity with unclear etiopathogenesis. Some studies have revealed that CAE may be a form of atherosclerosis that has more localized and intense inflammatory properties than atherosclerosis. The goal of this study was to investigate YKL-40 and C-reactive protein (CRP) levels in patients with isolated CAE compared to patients with normal coronary arteries (NCA) and coronary artery disease (CAD). Methods: Our study has an observational and cross-sectional design. Forty-nine patients with isolated CAE (mean age: 60±10 years), 30 age-and gender-matched control participants with NCA (30 patients, mean age: 58±12 years) and 30 patients with CAD (mean age: 61±10 years), were included in the study. The relationship between YKL-40, CRP levels and the presence of CAE was investigated. Univariate and multiple logistic regression analysis were used for analysis of independent variables to predict CAE. Results: Serum YKL-40 levels were significantly different among study groups (NCA: 110±53 μg/L, CAE: 144±68 and CAD: 180±117, p=0.005). CAD group and CAE group had significantly higher YKL-40 levels than NCA group (p=0.004 and p=0.015, respectively). CRP was not significantly different between three groups. In addition, there were no any statistically significant differences, with respect to age, gender, the presence of hypertension or diabetes mellitus, and the smoking status (p>0.05). Logistic regression analysis revealed only YKL-40 level as the determinant of CAE (OR: 1.010, 95% CI: 1.001-1.019, p=0.027). Conclusion: YKL-40 levels in patients with isolated CAE compared to patients with NCA were found significantly high and only YKL-40 level was established as the determinant of CAE. We believe that further studies are needed to clarify the possible causative roles of YKL-40 in patients with isolated CAE. (

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“…YKL-40 shares significant amino acid sequence homology to bacterial chitinases (2,9) and to six ''mammalian chitinase -like proteins'': oviduct-specific glycoprotein (10,11), chitotriosidase (12), YKL-39 (13), TSA 1902 (14), inducible silicotic bronchoalveolar lavage protein-p 58 (15) also named acidic mammalian chitinase (16), and mouse Ym1 (17) also named eosinophil chemotactic cytokine (18). Interestingly, Drosophila melanogaster secretes several proteins, DS47 and imaginal disc growth factors, with sequence homology to YKL-40 (19,20).…”

Section: Ykl-40mentioning

confidence: 99%