An Accurate Methodology to detect Leaching of Nickel and Chromium Ions in the Initial Phase of Orthodontic Treatment: An in vivo Study

Kumar, Raj; N, Rajvikram; Rajakumar, Perumal; Saravanan, R.; Va, Deepak; Vijaykumar,

doi:10.5005/jp-journals-10024-1828

Cited by 6 publications

(3 citation statements)

References 8 publications

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“…Table 2 shows the characteristics of 14 studies included in this meta-analysis. Four studies had been conducted in India [2,10,22,23], three in Iran [24,25,26], one in Norway [5], one in Turkey [13], one in Brazil [11], one in Greece [4], one in Morocco [6], one in Saudi Arabia [15], and one in Germany [1]. Two studies [1,22] reported the median (quartile) of the salivary level of ions, two studies [4,5] reported the median (range), and one study [6] reported the mean (range) values.…”

Section: Resultsmentioning

confidence: 99%

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Effect of Fixed Orthodontic Treatment on Salivary Nickel and Chromium Levels: A Systematic Review and Meta-Analysis of Observational Studies

2019

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Nickel and chromium ions released from fixed orthodontic appliances may act as allergens. This study aimed to systematically review the effect of fixed orthodontic treatment on salivary levels of these ions by doing a meta-analysis on cross-sectional and cohort studies. The Web of Science, Scopus, Cochrane Library, and PubMed databases were searched for articles on salivary profile of nickel or chromium in patients under fixed orthodontic treatment published from January 1983 to October 2017. A random-effect meta-analysis was done using Review Manager 5.3 to calculate mean difference (MD) and 95% confidence interval (CI), and the quality of questionnaire was evaluated by the Newcastle–Ottawa scale. Fourteen studies were included and analyzed in this meta-analysis. Salivary nickel level was higher in periods of 10 min or less (MD = −11.5 µg/L, 95% CI = −16.92 to −6.07; P < 0.0001) and one day (MD = −1.38 µg/L, 95% CI = −1.97 to −0.80; P < 0.00001) after initiation of treatment compared to baseline (before the insertion of appliance). Salivary chromium level was higher in periods of one day (MD = −6.25 µg/L, 95% CI = −12.00 to −0.49; P = 0.03) and one week (MD = −2.07 µg/L, 95% CI = −3.88 to −0.26; P = 0.03) after the initiation of treatment compared to baseline. Corrosion of fixed orthodontic appliances leads to elevated salivary nickel and chromium concentrations early after initiation of orthodontic treatment. Randomized clinical trials controlling for factors affecting the saliva composition are recommended on a higher number of patients and among different ethnicities.

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Section: Resultsmentioning

confidence: 99%

“…Two studies [1,22] reported the median (quartile) of the salivary level of ions, two studies [4,5] reported the median (range), and one study [6] reported the mean (range) values. Three studies [2,6,23] had only evaluated one assessment period of orthodontic treatment. Three studies did not report the mean age [1,2,11].…”

Section: Resultsmentioning

confidence: 99%

Effect of Fixed Orthodontic Treatment on Salivary Nickel and Chromium Levels: A Systematic Review and Meta-Analysis of Observational Studies

2019

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“…Kumar et al [ 37 ] evaluated the release of nickel and chromium ions in human saliva during fixed orthodontic therapy, pointed out on more intense release during the initial phase, by measuring the level of metal ions in saliva (by ICP-OES). The levels of nickel and chromium were statistically significantly higher, while nickel showed a gradual increase in the first 10 days with a further decline.…”

Section: Discussionmentioning

confidence: 99%

Do Dietary Habits Influence Trace Elements Release from Fixed Orthodontic Appliances?

Wołowiec

Chojnacka

Loster

et al. 2017

Biol Trace Elem Res

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The objective was to investigate the effect of dietary habits on the release of Cr and Ni ions from orthodontic appliances by hair mineral analysis. Patients (N = 47) underwent electronic questionnaire survey to investigate the effect of dietary habits on Cr and Ni levels in hair. The research was carried out on hair sampled at the beginning and in the 4th, 8th, and 12th months of the treatment. The content of Cr and Ni in the collected samples was determined by ICP-OES. The study showed that consumption of acidic dietary products may have the effect on increasing the release of Cr and Ni ions from orthodontic appliances. The release of Cr from orthodontic appliances in patients who consumed fruit juice, coffee, yoghurt, and vinegar was higher. The coefficients enabling comparison of metal ions release pattern at a given sampling points were defined. The comparison of the coefficients yielded the information on the possible magnification of metal ions released as the result of the additional factor consumption of acidic food or drink that intensifies metal ions release. The following magnification pattern was found for chromium: coffee (7.57 times) > yoghurt (2.53) > juice (1.86) > vinegar (1.08), and for nickel: vinegar (2.2) > coffee (1.22) > juice (1.05). Yoghurt did not intensify the release of nickel. Concluding, orthodontic patients should avoid drinking/eating coffee, yoghurt, fruit juices, and vinegar.

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Salivary levels of nickel, chromium, iron, and copper in patients treated with metal or esthetic fixed orthodontic appliances: A retrospective cohort study

Lages

Bridi

Pérez

et al. 2017

Journal of Trace Elements in Medicine and Biology

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An Accurate Methodology to detect Leaching of Nickel and Chromium Ions in the Initial Phase of Orthodontic Treatment: An in vivo Study

Abstract: Nickel and chromium levels were well within the permissible levels. However, some hypersensitive individuals may be allergic to this minimal permissible level.

Cited by 6 publications

References 8 publications

Effect of Fixed Orthodontic Treatment on Salivary Nickel and Chromium Levels: A Systematic Review and Meta-Analysis of Observational Studies

Effect of Fixed Orthodontic Treatment on Salivary Nickel and Chromium Levels: A Systematic Review and Meta-Analysis of Observational Studies

Do Dietary Habits Influence Trace Elements Release from Fixed Orthodontic Appliances?

Salivary levels of nickel, chromium, iron, and copper in patients treated with metal or esthetic fixed orthodontic appliances: A retrospective cohort study

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