2023
DOI: 10.1371/journal.pbio.3002212
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An adhesion signaling axis involving Dystroglycan, β1-Integrin, and Cas adaptor proteins regulates the establishment of the cortical glial scaffold

Wenny Wong,
Jason A. Estep,
Alyssa M. Treptow
et al.

Abstract: The mature mammalian cortex is composed of 6 architecturally and functionally distinct layers. Two key steps in the assembly of this layered structure are the initial establishment of the glial scaffold and the subsequent migration of postmitotic neurons to their final position. These processes involve the precise and timely regulation of adhesion and detachment of neural cells from their substrates. Although much is known about the roles of adhesive substrates during neuronal migration and the formation of th… Show more

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Cited by 2 publications
(2 citation statements)
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“…Could there be another, yet unidentified, α-DG receptor at the plasma membrane? The recent observation that α-DG organizes and stabilizes the developing brain cortex basement membrane through β1-integrin signaling opens a new scenario characterized by a possible cross-talk between the two main ECM receptors ( Wong et al, 2023 ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Could there be another, yet unidentified, α-DG receptor at the plasma membrane? The recent observation that α-DG organizes and stabilizes the developing brain cortex basement membrane through β1-integrin signaling opens a new scenario characterized by a possible cross-talk between the two main ECM receptors ( Wong et al, 2023 ).…”
Section: Discussionmentioning
confidence: 99%
“…It was shown that in radial glial cells, α-DG maintains the proper organization and structure of the basement membrane by binding to β1-integrin through laminin. Downstream of this adhesion complex, Cas, a cytosolic adaptor protein known to participate in integrin adhesion complexes turnover, becomes phosphorylated and stimulates integrin signaling that is indispensable for a correct glial scaffold ( Wong et al, 2023 ).…”
Section: Dg Stabilizes Diverse Protein Complexes In Multiple Tissuesmentioning
confidence: 99%