An adjustable, safe and highly protective live-attenuated SARS-CoV-2 vaccine based on large-scale one-to-stop codon modifications
Martin Beer,
Jacob Schön,
Güliz Barut
et al.
Abstract:Vaccines are the most effective measure against COVID-19. However, novel and highly efficacious vaccines with simplified administration and broad immunogenicity, providing systemic and mucosal immunity are needed. Here, we show the development of live-attenuated vaccines (LAV) based on (i) recoding the SARS-CoV-2 genome to enrich for "one-to-stop" (OTS) codons, (ii) facilitating host responses by disabling non-structural-protein-1 (Nsp1) mediated translational repression, and deletion of open reading frames (O… Show more
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