An AIEgen‐Peptide Conjugate as a Phototheranostic Agent for Phagosome‐Entrapped Bacteria

Qi, Guobin; Hu, Fang; Kenry, Kenry; Shi, Leilei; Wu, Min; Liu, Bin

doi:10.1002/anie.201906099

Cited by 101 publications

(54 citation statements)

References 40 publications

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“…In a follow-up work, AIE photosensitizer (PyTPE-CRP) was tailored with caspase-1 responsive peptide, so that the bioconjugates can be efficiently cleaved, self-assemble, and activate bacterial theranostics on caspase-1 enzymeenriched macrophage phagosomes (Fig. 7c) [85]. Owing to short lifetime of ROS and high bacterial targeting (Fig.…”

Section: Aie Photosensitizers For Intracellular Bacteriamentioning

confidence: 99%

Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics

et al. 2020

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Rapid evolution and propagation of multidrug resistance among bacterial pathogens are outpacing the development of new antibiotics, but antimicrobial photodynamic therapy (aPDT) provides an excellent alternative. This treatment depends on the interaction between light and photoactivated sensitizer to generate reactive oxygen species (ROS), which are highly cytotoxic to induce apoptosis in virtually all microorganisms without resistance concern. When replacing light with low-frequency ultrasonic wave to activate sensitizer, a novel ultrasound-driven treatment emerges as antimicrobial sonodynamic therapy (aSDT). Recent advances in aPDT and aSDT reveal golden opportunities for the management of multidrug resistant bacterial infections, especially in the theranostic application where imaging diagnosis can be accomplished facilely with the inherent optical characteristics of sensitizers, and the generated ROS by aPDT/SDT cause broad-spectrum oxidative damage for sterilization. In this review, we systemically outline the mechanisms, targets, and current progress of aPDT/SDT for bacterial theranostic application. Furthermore, potential limitations and future perspectives are also highlighted.

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Section: Aie Photosensitizers For Intracellular Bacteriamentioning

confidence: 99%

Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics

et al. 2020

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“…Experiments were approved by the Animal Ethics Committee of Nankai University (Tianjin, China). Nude mice were used, as they are relatively vulnerable to bacterial infections and therefore used in many evaluations of new infection-control strategies ( 41 , 56 , 57 ). AIWs were implanted ( 42 ) under anesthesia.…”

Section: Methodsmentioning

confidence: 99%

Self-targeting, zwitterionic micellar dispersants enhance antibiotic killing of infectious biofilms—An intravital imaging study in mice

Tian

Liu

et al. 2020

Sci. Adv.

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Extracellular polymeric substances (EPS) hold infectious biofilms together and limit antimicrobial penetration and clinical infection control. Here, we present zwitterionic micelles as a previously unexplored, synthetic self-targeting dispersant. First, a pH-responsive poly(ε-caprolactone)-block-poly(quaternary-amino-ester) was synthesized and self-assembled with poly(ethylene glycol)-block-poly(ε-caprolactone) to form zwitterionic, mixed-shell polymeric micelles (ZW-MSPMs). In the acidic environment of staphylococcal biofilms, ZW-MSPMs became positively charged because of conversion of the zwitterionic poly(quaternary-amino-ester) to a cationic lactone ring. This allowed ZW-MSPMs to self-target, penetrate, and accumulate in staphylococcal biofilms in vitro. In vivo biofilm targeting by ZW-MSPMs was confirmed for staphylococcal biofilms grown underneath an implanted abdominal imaging window through direct imaging in living mice. ZW-MSPMs interacted strongly with important EPS components such as eDNA and protein to disperse biofilm and enhance ciprofloxacin efficacy toward remaining biofilm, both in vitro and in vivo. Zwitterionic micellar dispersants may aid infection control and enhance efficacy of existing antibiotics against remaining biofilm.

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“…Meanwhile, another type‐III theranostic probe, PyTPE‐CRP, was developed to achieve the same goal through specific enzyme activated cleavage of the probe . PyTPE‐CRP contains an AIE PS and an enzyme‐cleavable peptide (NEAYVHDAP), which can be cleaved between amino acids Asp and Ala by the casp‐1 enzyme activation during bacterial infection of macrophage.…”

Section: Biomedical Applications Of Aiegen Probesmentioning

confidence: 99%

Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications

Cai,

Liu

2020

Angewandte Chemie

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116

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The concept of aggregation‐induced emission (AIE) has opened new opportunities in many research fields. Motivated by the unique feature of AIE fluorogens (AIEgens), during the past decade, many AIE molecular probes and AIE nanoparticle (NP) probes have been developed for sensing, imaging and theranostic applications with excellent performance outperforming conventional fluorescent probes. This Review summarizes the latest advancement of AIE molecular probes and AIE NP probes and their emerging biomedical applications. Special focus is to reveal how the AIE probes are evolved with the development of new multifunctional AIEgens, and how new strategies have been developed to overcome the limitations of traditional AIE probes for more translational applications via fluorescence imaging, photoacoustic imaging and image‐guided photodynamic/photothermal therapy. The outlook discusses the challenges and future opportunities for AIEgens to advance the biomedical field.

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An AIEgen‐Peptide Conjugate as a Phototheranostic Agent for Phagosome‐Entrapped Bacteria

Cited by 101 publications

References 40 publications

Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics

Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics

Self-targeting, zwitterionic micellar dispersants enhance antibiotic killing of infectious biofilms—An intravital imaging study in mice

Aggregation‐Induced Emission: Recent Advances in Materials and Biomedical Applications

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