An altered cell-specific subcellular distribution of translesion synthesis DNA polymerase kappa (POLK) in aging neurons
Mofida Abdelmageed,
Premkumar Palanisamy,
Victoria Vernail
et al.
Abstract:Genomic stability is critical for cellular function, however, in the central nervous system highly metabolically active differentiated neurons are challenged to maintain their genome over the organismal lifespan without replication. DNA damage in neurons increases with chronological age and accelerates in neurodegenerative disorders, resulting in cellular and systemic dysregulation. Distinct DNA damage response strategies have evolved with a host of polymerases. The Y-family translesion synthesis (TLS) polymer… Show more
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