An Altered Microbiota in the Lower and Upper Female Reproductive Tract of Women with Recurrent Spontaneous Abortion

Liu, Fen-Ting; Yang, Shuo; Yang, Zhongping; Zhou, Ping; Peng, Tianliu; Yin, Jingwen; Ye, Zhenhong; Shan, Hongying; Yu, Yang; Li, Rong

doi:10.1128/spectrum.00462-22

Cited by 18 publications

(21 citation statements)

References 49 publications

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“…68 These results are in line with another study in which beta diversity was significantly higher in the recurrent miscarriage group than in the control group in the vaginal microbiota, cervical microbiota, and microbiota from uterine lavage fluid. 69 Further, the comparison between women with spontaneous abortion and women undergoing voluntary abortion showed a double phenomenon with the spontaneous abortion group: a reduction in the diversity of the rectal microbiota and an increased ratio of Firmicutes to Bacteroidetes, which may suggest that the inflammatory aspects of the rectal microbiome in women experiencing miscarriage could be more attributable to the general dysbiosis than to the presence of a specific pathogen. 70…”

Section: Fertility Complications and The Lower Reproductive Tract Mic...mentioning

confidence: 93%

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Microenvironment of the Lower Reproductive Tract: Focus on the Cervical Mucus Plug

Ruiz-Durán,

Tenorio,

Vico-Zúñiga

et al. 2023

Semin Reprod Med

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The female lower reproductive tract microbiota is a complex ecosystem comprising various microorganisms that play a pivotal role in maintaining women's reproductive well-being. During pregnancy, the vaginal microbiota undergoes dynamic changes that are important for a successful gestation. This review summarizes the implications of the cervical mucus plug microenvironment and its profound impact on reproductive health. Further, the symbiotic relationship between the vaginal microbiome and the cervical mucus plug is highlighted, with a special emphasis on how this natural barrier serves as a guardian against ascending infections. Understanding this complex host–microbes interplay could pave the way for innovative approaches to improve women's reproductive health and fertility.

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Section: Fertility Complications and The Lower Reproductive Tract Mic...mentioning

confidence: 93%

Section: Fertility Complications and The Lower Reproductive Tract Mic...mentioning

confidence: 99%

Microenvironment of the Lower Reproductive Tract: Focus on the Cervical Mucus Plug

Ruiz-Durán,

Tenorio,

Vico-Zúñiga

et al. 2023

Semin Reprod Med

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“…Changes in the composition of the vaginal microbiota are associated with RSA. 81,82 The female vagina is colonized by numerous species and quantities of microbial communities that work together to maintain a healthy vaginal microenvironment. Vaginal microbiota possesses three key characteristics: stability (the ability to remain stable under various conditions), resistance (the ability of the microbial community to withstand environmental changes), and resilience (the ability of the microbial community to recover after external environmental influences).…”

Section: Immune-mediated Effects Of Vaginal Microbiota Dysbiosis In Rsamentioning

confidence: 99%

“…Changes in the composition of the vaginal microbiota are associated with RSA 81,82 . The female vagina is colonized by numerous species and quantities of microbial communities that work together to maintain a healthy vaginal microenvironment.…”

Section: The Potential Immunomodulatory Factors In Rsamentioning

confidence: 99%

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Maternal‐fetal immunity and recurrent spontaneous abortion

Yao,

Ye,

Chen

et al. 2024

American J Rep Immunol

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Recurrent Spontaneous Abortion (RSA) is a common pregnancy complication, that has multifactorial causes, and currently, 40%–50% of cases remain unexplained, referred to as Unexplained RSA (URSA). Due to the elusive etiology and mechanisms, clinical management is exceedingly challenging. In recent years, with the progress in reproductive immunology, a growing body of evidence suggests a relationship between URSA and maternal‐fetal immunology, offering hope for the development of tailored treatment strategies. This article provides an immunological perspective on the pathogenesis, diagnosis, and treatment of RSA. On one hand, it comprehensively reviews the immunological mechanisms underlying RSA, including abnormalities in maternal‐fetal interface immune tolerance, maternal‐fetal interface immune cell function, gut microbiota‐mediated immune dysregulation, and vaginal microbiota‐mediated immune anomalies. On the other hand, it presents the diagnosis and existing treatment modalities for RSA. This article offers a clear knowledge framework for understanding RSA from an immunological standpoint. In conclusion, while the “layers of the veil” regarding immunological factors in RSA are gradually being unveiled, our current research may only scratch the surface. In terms of immunological etiology, effective diagnostic tools for RSA are currently lacking, and the efficacy and safety of immunotherapies, primarily based on lymphocyte immunotherapy and intravenous immunoglobulin, remain contentious.

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Investigating into microbiota in the uterine cavity of the unexplained recurrent pregnancy loss patients in early pregnancy

Bai,

Xu,

et al. 2024

Placenta

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An Altered Microbiota in the Lower and Upper Female Reproductive Tract of Women with Recurrent Spontaneous Abortion

Abstract: As an obstacle to pregnancy, recurrent spontaneous abortion (RSA) can be caused by a variety of factors, and a current understanding of the etiology of RSA is still lacking; half of cases have an unknown cause. A substantial fraction of patients show no improvement after treatment.

Cited by 18 publications

References 49 publications

Microenvironment of the Lower Reproductive Tract: Focus on the Cervical Mucus Plug

Microenvironment of the Lower Reproductive Tract: Focus on the Cervical Mucus Plug

Maternal‐fetal immunity and recurrent spontaneous abortion

Investigating into microbiota in the uterine cavity of the unexplained recurrent pregnancy loss patients in early pregnancy

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