2022
DOI: 10.3390/pharmaceutics14122573
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An Alternative Device for the Topical Treatment of Oral Cancer: Development and Ex-Vivo Evaluation of Imiquimod-Loaded Polysaccharides Formulations

Abstract: The topical use of imiquimod (IMQ), a non-specific immune response modifier, showed to be a promising therapeutic option for the early-stage treatment of some type of oral cancer, even when performed with a formulation (Aldara®) developed and approved for skin application. The aim of this work was the development of buccal formulations for the topical administration of IMQ with improved mucosal retention and reduced trans-mucosal permeation when compared to the reference formulation. Three different hydrogels … Show more

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Cited by 4 publications
(1 citation statement)
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“…The combination of polymers with different properties can generate formulations with improved characteristics. Mucoadhesive formulations, for instance, can be successfully prepared using several types of biodegradable and biocompatible polysaccharides, such as alginate, chitosan, carboxymethylated chitosan, xanthan gum, and alginate [ 12 , 13 ], among others.…”
Section: Introductionmentioning
confidence: 99%
“…The combination of polymers with different properties can generate formulations with improved characteristics. Mucoadhesive formulations, for instance, can be successfully prepared using several types of biodegradable and biocompatible polysaccharides, such as alginate, chitosan, carboxymethylated chitosan, xanthan gum, and alginate [ 12 , 13 ], among others.…”
Section: Introductionmentioning
confidence: 99%