An anti-herpes simplex virus-type 1 agent from Xylaria mellisii (BCC 1005)

Terpenoid and Phenolic Metabolites from the Fungus Xylaria sp. Associated with Termite Nests

“…), and a new tetralone ( ¼ 3,4-dihydronaphthalen-1(2H)-one) derivative, 4, along with nine known compounds, xylaric acid D (5), hydroheptelidic acid (6), gliocladic acid (7), chlorine heptelidic acid (8), trichoderonic acid A (9), 16-(ad-mannopyranosyloxy)isopimar-7-en-19-oic acid (10), 16-(a-d-glucopyranosyloxy)isopimar-7-en-19-oic acid (11), 5-carboxymellein (12), and naphthalen-1,8-diol 1-O-a-d-glucopyranoside (13) have been isolated from the solid culture of the ascomycete fungus Xylaria sp. associated with termite nest.…”

“…Previous investigations have revealed that fungi of the genus Xylaria are a rich source of structurally diverse natural products. Examples include the HIV-1 integrase inhibitor integric acid [1], the cytotoxic agents xyloallenolide A [2] and eremophilanolides [3], the antifungal metabolites multiplolides A and B [4], the acetylcholinesterase inhibitors xyloketals [5], the NPY Y5 receptor antagonists xylarenals A and B [6], the chemokine receptor antagonist 19,20-epoxycytochalasin Q [7], the anti-herpes simplex virus agent mellisol [8].…”

An [11]Cytochalasin Derivative from the Marine-Derived Fungus Xylaria sp. PSU-F100

“…Some of them exhibited interesting biological activities such as anti-herpes simplex virus-type 1, 1) antifungal 2) and anti-human immunodeficiency virus (HIV)-1 integrase 3) activities. We found that the ethyl acetate extract from the broth of Xylaria sp.…”

“…12) The plausible biogenetic pathway would involve the attachment of L-leucine, not Lphenylalanine which was incorporated in all cytochalasins isolated from the genus Xylaria, 1,4,[14][15][16][17][18] to the C 16 -polyketide unit. The isolation of RKS-1778, a key intermediate of the [11]cytochalasin group from a soil fungus Phoma sp.…”

Chemical investigation on the cultures of the fungus Xylaria carpophila

“…Previous studies revealed that isopimarane diterpene glycosides, 1 xylopimarane, 2 4,6,8 (14),22-tetraen-3-one, 3 xylarisin, 4 coloratin A, 5 kolokoside A, 6 cytochalasins, 7 clonostachydiol, 7 xylobovide, 7 07H239-A, 8 cytochalasin D, 9 multiplolides A and B, 10 sordaricin, 11 mellisol, 12 1,8-dihydroxynaphthol 1-O-α-glucopyranoside, 12 benzoquinones, 13 and integric acid 14 from some species of this genus showed diverse pharmacological properties, including cytotoxic, antimicrobial, antifungal, anthelmintic, antivirus, and antimalarial activities. But the chemical constituents of Xylaria carpophila have received little attention.…”