An antibacterial and self-healing hydrogel from aldehyde-carrageenan for wound healing applications

Khodaei, Taravat; Nourmohammadi, Jhamak; Ghaee, Azadeh; Khodaii, Zohreh

doi:10.1016/j.carbpol.2022.120371

Cited by 39 publications

(13 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The rate of spontaneous biomaterial degradation should coincide with the rate of formation of new tissue. 43 The incorporation of EDTA into the hydrogel led to a rise in weight reduction, and the highest level of biodegradation, 66 ± 1.92%, was obtained in the CMC/CMCS/EDTA 2% group 24 h post‐incubation. The weight loss levels were found be related to the hydrophilic nature of the bioactive compounds that were added.…”

Section: Discussionmentioning

confidence: 86%

“…The destiny of the biomaterials is a critical characteristic that dictates the biomaterial's biodegradation. The rate of spontaneous biomaterial degradation should coincide with the rate of formation of new tissue 43 . The incorporation of EDTA into the hydrogel led to a rise in weight reduction, and the highest level of biodegradation, 66 ± 1.92%, was obtained in the CMC/CMCS/EDTA 2% group 24 h post‐incubation.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Assessment of the ability of Pseudomonas aeruginosa and Staphylococcus aureus to create biofilms during wound healing in a rat model treated with carboxymethyl cellulose/carboxymethyl chitosan hydrogel containing EDTA

Kolarijani,

Mirzaii,

Zamani

et al. 2024

International Wound Journal

View full text Add to dashboard Cite

The primary objective of this study was to develop a carboxymethyl cellulose (CMC) and carboxymethyl chitosan (CMCS) hydrogel containing ethylene diamine tetra acetic acid (EDTA) as the materials for wound healing. CMC and CMCS solutions were prepared with a concentration of 4% (w/v). These solutions were made using normal saline serum with a concentration of 0.5% (v/v). Additionally, EDTA with the concentrations of 0.01%, 0.05%, 0.1%, 0.5%, 1%, and 2% (w/v) was included in the prepared polymer solution. The analysis of the hydrogels revealed that they possess porous structures with interconnected pores, with average in size 88.71 ± 5.93 μm. The hydrogels exhibited a swelling capacity of up to 60% of their initial weight within 24 h, as indicated by the weight loss and swelling measurements. The antibacterial experiments showed that the formulated CMC/CMCS/EDTA 0.5% hydrogel inhibited the growth of Staphylococcus aureus and Pseudomonas aeruginosa. Moreover, the produced hydrogels were haemocompatible and biocompatible. At the last stage, the evaluation of wound healing in the animal model demonstrated that the use of the produced hydrogels significantly improved the process of wound healing. Finally, the findings substantiated the effectiveness of the formulated hydrogels as the materials for promoting wound healing and antibacterial agents.

show abstract

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 97%

Assessment of the ability of Pseudomonas aeruginosa and Staphylococcus aureus to create biofilms during wound healing in a rat model treated with carboxymethyl cellulose/carboxymethyl chitosan hydrogel containing EDTA

Kolarijani,

Mirzaii,

Zamani

et al. 2024

International Wound Journal

View full text Add to dashboard Cite

show abstract

“…The industry's trend toward developing hybrid and composite hydrogels [12,15,52,[57][58][59][60][61][62] highlights the pursuit of materials with enhanced properties through the combination of polymers. Collagen's compatibility with chitosan [10,56] and poly(ethylene glycol) [13] highlights its significance due to its biocompatibility and biodegradability, emphasizing its value in biomedical applications.…”

Section: Figurementioning

confidence: 99%

“…The theory of wound moist healing, an injectable and self-healing hydrogel comprising collagen (COL), chitosan (CS), and oxidation-modified Konjac glucoman-nan (OKGM), which acts as a macromolecular crosslinker to construct dynamic Schiff base bonds [56]. The industry's trend toward developing hybrid and composite hydrogels [12,15,52,[57][58][59][60][61][62] highlights the pursuit of materials with enhanced properties through the combination of polymers. Collagen's compatibility with chitosan [10,56] and poly(ethylene glycol) [13] highlights its significance due to its biocompatibility and biodegradability, emphasizing its value in biomedical applications.…”

Section: Figurementioning

confidence: 99%

Advancements and Challenges in Self-Healing Hydrogels for Wound Care

Omidian,

Wilson,

Gill

2024

Gels

View full text Add to dashboard Cite

This manuscript explores self-healing hydrogels as innovative solutions for diverse wound management challenges. Addressing antibiotic resistance and tailored wound care, these hydrogels exhibit promising outcomes, including accelerated wound closure and tissue regeneration. Advancements in multifunctional hydrogels with controlled drug release, antimicrobial properties, and real-time wound assessment capabilities signal a significant leap toward patient-centered treatments. However, challenges such as scalability, long-term safety evaluation, and variability in clinical outcomes persist. Future directions emphasize personalized medicine, manufacturing innovation, rigorous evaluation through clinical trials, and interdisciplinary collaboration. This manuscript features the ongoing pursuit of effective, adaptable, and comprehensive wound care solutions to transform medical treatments and improve patient outcomes.

show abstract

“…T. Khodaei et al (2023) obtained and characterized the self-healing aldehyde-carrageenan hydrogel for use in wound healing applications [ 176 ]. Carrageenan was oxidized with sodium periodate (NaIO 4 ) and then hydrogels using dopamine (PDA) and zinc ions (Zn 2+ ) (H-OCA-Dop-Zn) were synthesized.…”

Section: Natural Polymers With Antibacterial and Bacteriostatic Prope...mentioning

confidence: 99%

Biodegradable Polymers and Polymer Composites with Antibacterial Properties

Smola-Dmochowska

Lewicka

Macyk

et al. 2023

IJMS

View full text Add to dashboard Cite

Antibiotic resistance is one of the greatest threats to global health and food security today. It becomes increasingly difficult to treat infectious disorders because antibiotics, even the newest ones, are becoming less and less effective. One of the ways taken in the Global Plan of Action announced at the World Health Assembly in May 2015 is to ensure the prevention and treatment of infectious diseases. In order to do so, attempts are made to develop new antimicrobial therapeutics, including biomaterials with antibacterial activity, such as polycationic polymers, polypeptides, and polymeric systems, to provide non-antibiotic therapeutic agents, such as selected biologically active nanoparticles and chemical compounds. Another key issue is preventing food from contamination by developing antibacterial packaging materials, particularly based on degradable polymers and biocomposites. This review, in a cross-sectional way, describes the most significant research activities conducted in recent years in the field of the development of polymeric materials and polymer composites with antibacterial properties. We particularly focus on natural polymers, i.e., polysaccharides and polypeptides, which present a mechanism for combating many highly pathogenic microorganisms. We also attempt to use this knowledge to obtain synthetic polymers with similar antibacterial activity.

show abstract

An antibacterial and self-healing hydrogel from aldehyde-carrageenan for wound healing applications

Cited by 39 publications

References 39 publications

Assessment of the ability of Pseudomonas aeruginosa and Staphylococcus aureus to create biofilms during wound healing in a rat model treated with carboxymethyl cellulose/carboxymethyl chitosan hydrogel containing EDTA

Assessment of the ability of Pseudomonas aeruginosa and Staphylococcus aureus to create biofilms during wound healing in a rat model treated with carboxymethyl cellulose/carboxymethyl chitosan hydrogel containing EDTA

Advancements and Challenges in Self-Healing Hydrogels for Wound Care

Biodegradable Polymers and Polymer Composites with Antibacterial Properties

Contact Info

Product

Resources

About