An Antibiotic from Spiræa aruncus L

Phytochemical, pharmacological and toxicological studies of alkaloid- and sesquiterpene lactone-containing medicinal plants

“…In one of our previous papers our group reported that aconitine (18), 14-benzoylaconine 8-O-palmitate (35), gigactonine (12), neolinine (16) and songoramine (31) demonstrated significant hERG channel inhibition using whole-cell patch clamp technique [105]. In a subsequent study, 15 diterpene alkaloids (aconosine 2 Aqueous extract of S. aruncus [170] and alcoholic extract of S. thunbergii exerted antibacterial effect in vitro [171]. The volatile oils of S. alpina [172] and the decoction of S. salicifolia [173] exerted antifungal activity, similarly to the flavonoids and polyphenolic compounds isolated from Spiraea species [140,174,175].…”