An antisense oligonucleotide carrier based on amino silica nanoparticles for antisense inhibition of cancer cells

Review: Bioanalytical applications of biomolecule-functionalized nanometer-sized doped silica particles

“…However, the application of therapies based on anti-ODNs is hampered by their instability (to cellular nuclease) and their weak intracellular penetration. Thus, to increase their stability and improve intracellular delivery, positively charged silica nanoparticles have been used and examined with anti-ODNs and A549 cell lines [163]. Compared with liposomes, the positively charged amino silica nanoparticles (NH 2 SiNP) presented a better biocompatibility and had almost no cytotoxicity at the concentrations required for efficient transfection.…”

Albumin-bound formulation of paclitaxel (Abraxane® ABI-007) in the treatment of breast cancer

“…Most well studied are liposomes, 36 dendrimers, 37,38 super paramagnetic nanoparticulates, 39,40 polymer-based platforms, 41,42 gold nanoshells, 43,44 silicon-and silica-based nanoparticles, [45][46][47] carbon-60 fullerenes, 48 and nanocrystals. 49 They can be divided into three generations of compound, according to whether or not they were developed to target a specifi c target which is expressed on the tumor cells or the endothelium.…”

Microemulsions - A Brief Introduction

“…Among them is the delivering of genes into the cells (Gupta et al, 2004), with the aim of treatment of disease or diagnosis (Pedersen et al, 2006, Peng et al, 2006, Xu et al, 2011, Rossi et al, 2006, Santra et al, 2005, targeting cancer cell (Tao et al, 2011, Lu et al, 2008, Reithofer et al, 2011, act as vaccine (Sun et al, 2009, Mumper & Cui, 2003, biocatalyss (Stamatis & Xenakis, 1999, Zoumpanioti et al, 2010, Blattner et al, 2006, cosmetics (Chiu & Yang, 1992, Förster et al, 1995, Valenta & Schultz, 2004, Teichmann et al, 2007 or changing the genetic to improve the performance of the targeted cells , Courrier et al, 2004.…”