An application of carbohydrate polymers-based surface-modified gold nanoparticles for improved target delivery to liver cancer therapy - A systemic review

Alzahrani, Abdullah R.; Ibrahim, Ibrahim Abdel Aziz; Shahzad, Naiyer; Shahid, Imran; Alanazi, Ibrahim M.; Falemban, Alaa Hisham; Azlina, Mohd Fahami Nur

doi:10.1016/j.ijbiomac.2023.126889

Cited by 8 publications

(4 citation statements)

References 236 publications

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“…Gold nanoparticles (AuNPs) are frequently employed as signal transducers in biosensing . The binding of the target analyte to the functionalized gold nanoparticles (AuNPs) results in alterations in the local refractive index and the interparticle distance .…”

Section: Gold Nanoparticle Applications In Biosensorsmentioning

confidence: 99%

“…Their use in various synthetic approaches allows researchers to tailor GNP size, shape, and surface properties, thereby fine-tuning the nanoparticles for specific applications . Moreover, gold(III) chloride complexes are amenable to surface modification, enabling the attachment of functional groups that enhance the stability and biocompatibility of GNPs in biological and medical applications . Gold’s remarkable ability to adopt multiple oxidation states, particularly Au(I) and Au(III), underpins its utility in forming stable complexes, making it a valuable element in various chemical and nanotechnological applications.…”

Section: General Chemistries Of Gold (Auric- (Au))mentioning

confidence: 99%

“… 21 Moreover, gold(III) chloride complexes are amenable to surface modification, enabling the attachment of functional groups that enhance the stability and biocompatibility of GNPs in biological and medical applications. 22 Gold’s remarkable ability to adopt multiple oxidation states, particularly Au(I) and Au(III), underpins its utility in forming stable complexes, making it a valuable element in various chemical and nanotechnological applications. Understanding the principles governing the stability of gold complexes and the choice of precursor compounds is essential for advancing the field of nanotechnology and harnessing the unique properties of gold nanoparticles for diverse scientific and technological endeavors.…”

Section: General Chemistries Of Gold (Auric- (Au))mentioning

confidence: 99%

“…88 Gold nanoparticles (AuNPs) are frequently employed as signal transducers in biosensing. 22 The binding of the target analyte to the functionalized gold nanoparticles (AuNPs) results in alterations in the local refractive index and the interparticle distance. 89 The modifications in the surrounding conditions of the nanoparticle lead to a modification in the wavelength of their surface plasmonic resonance (SPR) or a variation in their visual appearance, which can be detected or measured using spectroscopic methods.…”

Section: Gold Nanoparticle Applications In Biosensorsmentioning

confidence: 99%

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Gold Nanoparticles in Nanobiotechnology: From Synthesis to Biosensing Applications

Karnwal,

Kumar Sachan,

Devgon

et al. 2024

ACS Omega

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Nanobiotechnology has ushered in a new era of scientific discovery where the unique properties of nanomaterials, such as gold nanoparticles, have been harnessed for a wide array of applications. This review explores gold nanoparticles' synthesis, properties, and multidisciplinary applications, focusing on their role as biosensors. Gold nanoparticles possess exceptional physicochemical attributes, including size-dependent optical properties, biocompatibility, and ease of functionalization, making them promising candidates for the development of biosensing platforms. The review begins by providing a comprehensive overview of gold nanoparticle synthesis techniques, highlighting the advantages and disadvantages of various approaches. It then delves into the remarkable properties that underpin their success in biosensing, such as localized surface plasmon resonance and enhanced surface area. The discussion also includes the functionalization strategies that enable specific binding to biomolecules, enhancing the sensitivity and selectivity of gold-nanoparticle-based biosensors. Furthermore, this review surveys the diverse applications of gold nanoparticles in biosensing, encompassing diagnostics, environmental monitoring, and drug delivery. The multidisciplinary nature of these applications underscores the versatility and potential of gold nanoparticles in addressing complex challenges in healthcare and environmental science. The review emphasizes the pressing need for further exploration and research in the field of nanobiotechnology, particularly regarding the synthesis, properties, and biosensing applications of gold nanoparticles. With their exceptional physicochemical attributes and versatile functionalities, gold nanoparticles present a promising avenue for addressing complex challenges in healthcare and environmental science, making it imperative to advance our understanding of their synthesis, properties, and applications for enhanced biosensing capabilities and broader scientific innovation.

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Section: Gold Nanoparticle Applications In Biosensorsmentioning

confidence: 99%

Section: General Chemistries Of Gold (Auric- (Au))mentioning

confidence: 99%

Section: General Chemistries Of Gold (Auric- (Au))mentioning

confidence: 99%

Section: Gold Nanoparticle Applications In Biosensorsmentioning

confidence: 99%

See 2 more Smart Citations

Gold Nanoparticles in Nanobiotechnology: From Synthesis to Biosensing Applications

Karnwal,

Kumar Sachan,

Devgon

et al. 2024

ACS Omega

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Bioengineered carbohydrate polymers for colon‐specific drug release: Current trends and future prospects

Bhirud,

Bhattacharya,

Prajapati

2024

J Biomedical Materials Res

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The worldwide health burden of colorectal cancer is still substantial, and traditional chemotherapeutic drugs sometimes have poor selectivity, which can result in systemic toxicity and unfavorable side effects. For colon‐specific medication delivery, bioengineered carbohydrate polymers have shown promise as carriers. They may enhance treatment effectiveness while minimizing systemic exposure and associated side effects. The unique properties of these manufactured or naturally occurring biopolymers, such as hyaluronic acid, chitosan, alginate, and pectin, enable targeted medicine release. These qualities can be changed to meet the physiological needs of the colon. In the context of colorectal cancer therapy, this article provides a comprehensive overview of current developments and prospective future directions in the field of bioengineered carbohydrate polymer synthesis for colon‐specific drug delivery. We discuss numerous techniques for achieving colon‐targeted drug release, including enzyme‐sensitive polymers, pH‐responsive devices, and microbiota‐activated processes. To increase tumor selectivity and cellular uptake, we also examine the inclusion of active targeting approaches, such as conjugating specific ligands. Furthermore, we discuss the potential of combination treatment strategies, which use the coadministration of numerous therapeutic medications to target multiple pathways implicated in cancer growth and address drug resistance mechanisms. We address recent biomimetic advances that potentially improve the biocompatibility, cellular uptake, and tumor penetration of carbohydrate polymer‐based nanocarriers. These methods involve protein corona engineering and cell membrane coating. Furthermore, we look at the possibility of intelligent and sensitive systems that may adjust their behaviors in response to certain inputs or feedback loops, allowing for precise and regulated drug distribution.

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Classes/types of polymers used in oral delivery (natural, semisynthetic, synthetic), their chemical structure and general functionalities

Datta,

Colaco,

Bandi

et al. 2025

Polymers for Oral Drug Delivery Technologies

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An application of carbohydrate polymers-based surface-modified gold nanoparticles for improved target delivery to liver cancer therapy - A systemic review

Cited by 8 publications

References 236 publications

Gold Nanoparticles in Nanobiotechnology: From Synthesis to Biosensing Applications

Gold Nanoparticles in Nanobiotechnology: From Synthesis to Biosensing Applications

Bioengineered carbohydrate polymers for colon‐specific drug release: Current trends and future prospects

Classes/types of polymers used in oral delivery (natural, semisynthetic, synthetic), their chemical structure and general functionalities

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