An Approach for the Estimation of Concentrations of Soluble Compounds in E. coli Bioprocesses
Deividas Masaitis,
Renaldas Urniezius,
Rimvydas Simutis
et al.
Abstract:Accurate estimations of the concentrations of soluble compounds are crucial for optimizing bioprocesses involving Escherichia coli (E. coli). This study proposes a hybrid model structure that leverages off-gas analysis data and physiological parameters, including the average biomass age and specific growth rate, to estimate soluble compounds such as acetate and glutamate in fed-batch cultivations We used a hybrid recurrent neural network to establish the relationships between these parameters. To enhance the p… Show more
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