An Approach to Chemotherapy-Associated Toxicity

Livshits, Zhanna; Rao, Rama; Smith, Silas W.

doi:10.1016/j.emc.2013.09.002

Cited by 142 publications

(108 citation statements)

References 65 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A anemia é definida como a "condição em que ocorre deficiência de células vermelhas, hemoglobina ou no volume total" (8) , ocorrendo com frequência em virtude do câncer ou do tratamento antineoplásico (9) , resultando em anemia hemolítica para os indivíduos em uso de procarbazina e fludarabina (10) . É possível observar ao exame clínico a palidez de mucosas, esplenomegalia e caquexia em indivíduos anêmicos (9) , assim como sintomas de fraqueza generalizada, intolerância a exercícios físicos e dispnéia.…”

Section: B) Alterações No Hemograma E Mielossupressãounclassified

“…É possível observar ao exame clínico a palidez de mucosas, esplenomegalia e caquexia em indivíduos anêmicos (9) , assim como sintomas de fraqueza generalizada, intolerância a exercícios físicos e dispnéia. Os casos mais graves podem evoluir com déficit na oxigenação tecidual e isquemia de orgãos terminais (10) . Os procedimentos cirúrgicos bucais não deverão ser realizados nos indivíduos com anemia intensa, devido o alto potencial de sangramento secundário e capacidade de reparação tecidual diminuída.…”

Section: B) Alterações No Hemograma E Mielossupressãounclassified

“…A contagem de leucócitos pode variar nos indivíduos saudáveis de acordo com atividade física, estado emocional e momento do dia (13,15) . Durante a QT a leucopenia representa uma complicação importante e frequentemente observada nos indivíduos que fazem uso de docetaxel e paclitaxel (10) entre o sexto e o décimo dia após a QT (1) . Nesses casos existe aumento do risco de infecções decorrentes da flora endógena da região oral, podendo resultar em infecções graves (13,15) .…”

Section: B) Alterações No Hemograma E Mielossupressãounclassified

See 2 more Smart Citations

Avaliação perioperatória de indivíduos em quimioterapia com necessidade de intervenção cirúrgica odontológica

Duarte¹,

Maciel²,

Gonçales³

et al. 2018

Arq Med Hosp Fac Cienc Med Santa Casa São Paulo

View full text Add to dashboard Cite

Section: B) Alterações No Hemograma E Mielossupressãounclassified

See 1 more Smart Citation

Avaliação perioperatória de indivíduos em quimioterapia com necessidade de intervenção cirúrgica odontológica

Duarte¹,

Maciel²,

Gonçales³

et al. 2018

Arq Med Hosp Fac Cienc Med Santa Casa São Paulo

View full text Add to dashboard Cite

“…11 The breadth of cancer chemotherapeutic agents is vast, which is actually beneficial as most cancer patients receive multi-drug regimens. This is due to the inherent complexity of cancer 12 -a non-responder to one chemotherapeutic agent may respond to another. In this review, we focus on traditional cytotoxic chemotherapeutic drugs.…”

mentioning

confidence: 99%

“…18 Cytotoxic chemotherapeutic drugs can be roughly divided into alkylating agents, antimetabolites, natural products, hormones and hormone antagonists, and other miscellaneous agents. 10,12,19 Alkylating agents…”

mentioning

confidence: 99%

Overcoming tumor cell chemoresistance using nanoparticles: lysosomes are beneficial for (stearoyl) gemcitabine-incorporated solid lipid nanoparticles

Chen¹,

Zheng²,

Shi³

et al. 2018

IJN

View full text Add to dashboard Cite

Despite recent advances in targeted therapies and immunotherapies, chemotherapy using cytotoxic agents remains an indispensable modality in cancer treatment. Recently, there has been a growing emphasis in using nanomedicine in cancer chemotherapy, and several nanomedicines have already been used clinically to treat cancers. There is evidence that formulating small molecular cancer chemotherapeutic agents into nanomedicines significantly modifies their pharmacokinetics and often improves their efficacy. Importantly, cancer cells often develop resistance to chemotherapy, and formulating anticancer drugs into nanomedicines also helps overcome chemoresistance. In this review, we briefly describe the different classes of cancer chemotherapeutic agents, their mechanisms of action and resistance, and evidence of overcoming the resistance using nanomedicines. We then emphasize on gemcitabine and our experience in discovering the unique (stearoyl) gemcitabine solid lipid nanoparticles that are effective against tumor cells resistant to gemcitabine and elucidate the underlying mechanisms. It seems that lysosomes, which are an obstacle in the delivery of many drugs, are actually beneficial for our (stearoyl) gemcitabine solid lipid nanoparticles to overcome tumor cell resistance to gemcitabine.

show abstract

The Janus Nature of Nanohydroxyapatite in Tumor Progression

Shen

Wan

et al. 2021

Adv Funct Materials

View full text Add to dashboard Cite

Nanohydroxyapatite (nHAP) has broad applications because of its nanoscopical dimension, large specific surface area, biocompatibility, and low cytotoxicity. Researchers recently discovered that nHAP synthesized in vitro inhibits the growth of different types of tumor cells. Nanohydroxyapatite with potent drug adsorption and loading capacity has potential applications in tumor diagnosis and treatment. Because local tumors and areas of tumor metastasis also produce pathological nHAP in vivo to promote progression and invasion, the role of nHAP in tumorigenesis and development is perceived literature by many as Janus, the double‐faced deity in ancient Roman mythology. In the present review, two types of nHAP (those synthesized in vitro and those produced in vivo) that are affiliated with tumors, their mechanisms in tumor progression as well as their applications in tumor treatment are elucidated to create a backdrop for future research in this exciting, yet controversial arena.

show abstract

An Approach to Chemotherapy-Associated Toxicity

Cited by 142 publications

References 65 publications

Avaliação perioperatória de indivíduos em quimioterapia com necessidade de intervenção cirúrgica odontológica

Avaliação perioperatória de indivíduos em quimioterapia com necessidade de intervenção cirúrgica odontológica

Overcoming tumor cell chemoresistance using nanoparticles: lysosomes are beneficial for (stearoyl) gemcitabine-incorporated solid lipid nanoparticles

The Janus Nature of Nanohydroxyapatite in Tumor Progression

Contact Info

Product

Resources

About