An approach to develop clinical prediction rule for candidemia in critically ill patients: A retrospective observational study

Jameran, Ahmad Shafie; Cheah, Saw Kian; Khaithir, Tzar Mohd Nizam; Musthafa, Qurratu Aini; Low, Hsueh Jing; Maaya, Muhammad; Rahman, Raha Abdul

doi:10.1016/j.jcrc.2021.06.018

Cited by 4 publications

(1 citation statement)

References 35 publications

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“…Although Candida risk/colonization scores have shown potential for identifying patients at increased risk of IC, the significant number of clinical interventions and the necessary duration of admission in the ICU mean that critical-care COVID-19 patients are likely exposed to prolonged risk of invasive candidosis [ 18 ▪ , 40 , 49 , 50 ]. It remains unclear what combination of tests will prove optimal for the diagnosis of invasive candidosis in either the COVID-19 or non-COVID-19 population, but a likely combination of molecular, serological and conventional testing will cover the range of targets potentially available in cases of invasive candidosis and when all tests are negative invasive candidosis will be unlikely [ 51 ].…”

Section: Diagnosis Of Coronavirus Disease-2019-associated Candidosismentioning

confidence: 99%

Diagnosis of invasive fungal disease in coronavirus disease 2019: approaches and pitfalls

White

2021

Current Opinion in Infectious Diseases

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Purpose of reviewThis review will comment on the current knowledge for the diagnosis of the main causes of COVID-19associated invasive fungal disease (IFD); it will discuss the optimal strategies and limitations and wherever available, will describe international recommendations.Recent findings A range of secondary IFDs complicating COVID-19 infection have been described and while COVID-19associated pulmonary aspergillosis was predicted, the presentation of significant numbers of COVID-19associated candidosis and COVID-19-associated mucormycosis was somewhat unexpected. Given the range of IFDs and prolonged duration of risk, diagnostic strategies need to involve multiple tests for detecting and differentiating various causes of IFD. Although performance data for a range of tests to diagnose COVID-19-associated pulmonary aspergillosis is emerging, the performance of tests to diagnose other IFD is unknown or based on pre-COVID performance data.

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Section: Diagnosis Of Coronavirus Disease-2019-associated Candidosismentioning

confidence: 99%

Diagnosis of invasive fungal disease in coronavirus disease 2019: approaches and pitfalls

White

2021

Current Opinion in Infectious Diseases

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Empirical Therapy for Invasive Candidiasis in Critically Ill Patients

Bartalucci,

Giacobbe,

Vena

et al. 2024

Curr Fungal Infect Rep

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Purpose of Review In this narrative review, we discuss recent literature regarding early antifungal therapy in critically ill patients, focusing in particular on the current role of empirical antifungal treatment. Recent Findings While the direction of effect in randomized controlled trials (RCTs) exploring efficacy of empirical therapy in intensive care unit (ICU) patients with suspected invasive candidiasis (IC) was most frequently toward a favorable impact of empirical therapy, no formal demonstration of superiority was observed. Summary Main results from RCTs seem in contrast with the increased mortality reported from observational studies in case of delayed antifungal therapy in patients with IC, suggesting, in our opinion, that further research is still necessary to better delineate the precise subgroup of ICU patients with suspected IC who may benefit from early antifungal therapy, either early empirical based on risk scores or diagnostic-driven, or a combination of both.

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Secondary fungal infections in SARS-CoV-2 patients: pathological whereabouts, cautionary measures, and steadfast treatments

et al. 2023

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An approach to develop clinical prediction rule for candidemia in critically ill patients: A retrospective observational study

Cited by 4 publications

References 35 publications

Diagnosis of invasive fungal disease in coronavirus disease 2019: approaches and pitfalls

Diagnosis of invasive fungal disease in coronavirus disease 2019: approaches and pitfalls

Empirical Therapy for Invasive Candidiasis in Critically Ill Patients

Secondary fungal infections in SARS-CoV-2 patients: pathological whereabouts, cautionary measures, and steadfast treatments

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