“…Therefore, adequate measures implemented in the design phase may result in safer plants from the point of view of escalation. Design optimization tools mainly focus on economic aspects, even if safety issues have been considered in some recent works (Díaz-Ovalle et al, 2010;Jung et al, 2010;Jung et al, 2011;Nolan and Bradley, 1987;Penteado and Ciric, 1996;Patsiatzis et al, 2004). Several tools can be applied in order to anticipate safety issues related to the prevention of escalation in layout design.…”