An aqueous-based process to bioactivate poly(ε-caprolactone)/mesoporous bioglass composite surfaces by prebiotic chemistry-inspired polymer coatings for biomedical applications

Cheng, Sheng-Ying; Chiang, Yu-Lun; Chang, Yang-Hua; Thissen, Helmut; Tsai, Shiao-Wen

doi:10.1016/j.colsurfb.2021.111913

Cited by 10 publications

(10 citation statements)

References 42 publications

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“…Recently, it has been shown that the particle morphology of the known HCN-derived polymers can be tuned by the choice of the synthetic conditions [ 1 , 2 , 3 ]. Some polymers of this heterogeneous family [ 4 ] have been proposed as emergent materials with different applications, such as photocatalysts [ 5 ], semiconductors, nanowires, ferroelectric materials [ 6 ], capacitors [ 1 ], coatings with potential biomedical applications [ 2 , 7 , 8 , 9 ], protective films against corrosion [ 10 , 11 ], or for the development of antimicrobial media for passive filtration [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Tuning the Morphology in the Nanoscale of NH4CN Polymers Synthesized by Microwave Radiation: A Comparative Study

et al. 2021

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A systematic study is presented to explore the NH4CN polymerization induced by microwave (MW) radiation, keeping in mind the recent growing interest in these polymers in material science. Thus, a first approach through two series, varying the reaction times and the temperatures between 130 and 205 °C, was conducted. As a relevant outcome, using particular reaction conditions, polymer conversions similar to those obtained by means of conventional thermal methods were achieved, with the advantage of a very significant reduction of the reaction times. The structural properties of the end products were evaluated using compositional data, spectroscopic measurements, simultaneous thermal analysis (STA), X-ray diffraction (XRD), and scanning electron microscopy (SEM). As a result, based on the principal component analysis (PCA) from the main experimental results collected, practically only the crystallographic features and the morphologies in the nanoscale were affected by the MW-driven polymerization conditions with respect to those obtained by classical syntheses. Therefore, MW radiation allows us to tune the morphology, size and shape of the particles from the bidimensional C=N networks which are characteristic of the NH4CN polymers by an easy, fast, low-cost and green-solvent production. These new insights make these macromolecular systems attractive for exploration in current soft-matter science.

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Section: Introductionmentioning

confidence: 99%

Tuning the Morphology in the Nanoscale of NH4CN Polymers Synthesized by Microwave Radiation: A Comparative Study

et al. 2021

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“…All security and safety measures were taken during the development of the experiments, considering the safety information provided by the Sigma-Aldrich supplier (St. Louis, MO, United States) about NaCN and NH 4 Cl. On the other hand, although HCN-derived polymers have been shown as biocompatible [ 19 , 20 , 21 , 22 , 23 , 24 ], the cyanide polymers synthesized in the present work were handled with the same security measures as NaCN.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, recently, HCN-derived polymers have received great attention in materials science [ 18 , 19 ]. Their tunable characteristics provide promising potential applications, such as coating materials of interest in biomedicine [ 19 , 20 , 21 , 22 , 23 , 24 ], as well as effective films against oxidation [ 25 , 26 ] and for the modification of electrodes for the development of biosensors [ 27 ]. Additionally, HCN-derived polymers have been tested as photocatalyzers [ 28 ], capacitors [ 29 ], semiconductors [ 30 ] and passive antimicrobial filters [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Multivariate Analysis Applied to Microwave-Driven Cyanide Polymerization: A Statistical View of a Complex System

et al. 2023

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For the first time, chemometrics was applied to the recently reported microwave-driven cyanide polymerization. Fast, easy, robust, low-cost, and green-solvent processes are characteristic of these types of reactions. These economic and environmental benefits, originally inspired by the constraints imposed by plausible prebiotic synthetic conditions, have taken advantage of the development of a new generation of HCN-derived multifunctional materials. HCN-derived polymers present tunable properties by temperature and reaction time. However, the apparently random behavior observed in the evolution of cyanide polymerizations, assisted by microwave radiation over time at different temperatures, leads us to study this highly complex system using multivariate analytical tools to have a proper view of the system. Two components are sufficient to explain between 84 and 98% of the total variance in the data in all principal component analyses. In addition, two components explain more than 91% of the total variance in the data in the case of principal component analysis for categorical data. These consistent statistical results indicate that microwave-driven polymerization is a more robust process than conventional thermal syntheses but also that plausible prebiotic chemistry in alkaline subaerial environments could be more complex than in the aerial part of these systems, presenting a clear example of the “messy chemistry” approach of interest in the research about the origins of life. In addition, the methodology discussed herein could be useful for the data analysis of extraterrestrial samples and for the design of soft materials, in a feedback view between prebiotic chemistry and materials science.

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“…Synthetic aliphatic polyesters, typically poly(lactic acid) (PLA), poly(glycolic acid) (PGA), poly(lactic acid-co-glycolic acid) (PLGA), and poly(ε-caprolactone) (PCL), are one type of the most studied biodegradable polymers for biomedical applications [23,24]. Based on the residue chirality, there are four types of PLA including poly(L-lactic acid) (PLLA), poly(D-lactic acid) (PDLA), poly(rac-D,L-lactic acid), and poly(meso-lactide).…”

Section: Aliphatic Polyestersmentioning

confidence: 99%

“…Based on the residue chirality, there are four types of PLA including poly(L-lactic acid) (PLLA), poly(D-lactic acid) (PDLA), poly(rac-D,L-lactic acid), and poly(meso-lactide). PLA, PGA, and PLGA have been approved by FDA for various clinical uses, such as absorbable sutures (DEXON® (PGA-based), Vicryl Ra-pide® (PLGA(10:90)-based)), bone fixation devices (Bio-fix® (PGA-or PLLA-based), Fixsorb® (PLLA-based)), facial fillers (Sculptra® (PLLA-based)), and drug delivery systems (Eligard® (Leuprolide acetate/PLGA)) [23][24][25]. Compared with the aforementioned polyesters, PCL shows obvious longer hydrolytic degradation time for over 2 years.…”

Section: Aliphatic Polyestersmentioning

confidence: 99%

Biomedical polymers: synthesis, properties, and applications

Chen

et al. 2022

Sci. China Chem.

117

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Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as therapeutic medicine delivery, disease detection and diagnosis, biosensing, regenerative medicine, and disease treatment. In this review, we summarize the most recent advances in the synthesis and application of biomedical polymers, and discuss the comprehensive understanding of their property-function relationship for corresponding biomedical applications. In particular, a few burgeoning bioactive polymers, such as peptide/biomembrane/microorganism/cell-based biomedical polymers, are also introduced and highlighted as the emerging biomaterials for cancer precision therapy. Furthermore, the foreseeable challenges and outlook of the development of more efficient, healthier and safer biomedical polymers are discussed. We wish this systemic and comprehensive review on highlighting frontier progress of biomedical polymers could inspire and promote new breakthrough in fundamental research and clinical translation.

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An aqueous-based process to bioactivate poly(ε-caprolactone)/mesoporous bioglass composite surfaces by prebiotic chemistry-inspired polymer coatings for biomedical applications

Cited by 10 publications

References 42 publications

Tuning the Morphology in the Nanoscale of NH4CN Polymers Synthesized by Microwave Radiation: A Comparative Study

Tuning the Morphology in the Nanoscale of NH4CN Polymers Synthesized by Microwave Radiation: A Comparative Study

Multivariate Analysis Applied to Microwave-Driven Cyanide Polymerization: A Statistical View of a Complex System

Biomedical polymers: synthesis, properties, and applications

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