An Arab selective gradient in the distribution of factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T

Ameen, Ghada; Irani-Hakime, Noha; Fawaz, Naglaa; Mahjoub, Touhami; Almawi, Wassim Y.

doi:10.1111/j.1538-7836.2005.01546.x

Cited by 20 publications

(12 citation statements)

References 10 publications

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“…One study suggested that the 1298C/C genotype may be protective of DN in the presence of low-normal folate concentrations (11). It is noteworthy that the prevalence of 677T/T among Bahrainis (2.0%) was lower than that in Caucasians (2,18), and a north-south gradient in its prevalence has been described (18), supporting the ethnic contribution of 677T/T to DN risk. MTHFR 677C/C was positively associated with DN in Lebanese but not Bahraini patients, in agreement with some (7,8), but not all (16,17) studies.…”

Section: Discussionmentioning

confidence: 98%

Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebanese and Bahraini Arabs

Nemr

Salman²,

Jawad³

et al. 2010

Clinical Chemistry and Laboratory Medicine

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Section: Discussionmentioning

confidence: 98%

Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebanese and Bahraini Arabs

Nemr

Salman²,

Jawad³

et al. 2010

Clinical Chemistry and Laboratory Medicine

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“…The risk for VTE in heterozygous carriers is estimated to be three-fold of that in noncarriers. The FII G20210A risk allele seems to be restricted quite exclusively in Caucasians with an overall frequency ranging from 0.6 % to 4.0 % in healthy people (52)(53)(54)(55)(56)(57)(58)(59)(60)(61)(62). The mutation is distributed more common in South than in North Europe (▶ Table 1), a gradient opposite to that of FV Leiden.…”

Section: Prothrombin G20210amentioning

confidence: 99%

Ethnic diversity in the genetics of venous thromboembolism

Tang¹,

Hu²

2015

Thromb Haemost

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Genetic susceptibility is considered as a crucial factor for the development of venous thromboembolism (VTE). Epidemiologic and genetic studies have revealed clear disparities in the incidence of VTE and the distribution of genetic factors for VTE in populations stratified by ethnicity worldwide. While gain-of-function polymorphisms in the procoagulant genes are common inherited factors in European-origin populations, the most prevalent molecular basis for venous thrombosis in Asians is confirmed to be dysfunctional variants in the anticoagulant genes. With the breakthrough of genomic technologies, a set of novel common alleles and rare mutations associated with VTE have also been identified, in different ethnic groups. Several putative pathways contributing to the pathogenesis of thrombophilia in populations of African-ancestry are largely unknown, as current knowledge of hereditary and acquired risk factors do not fully explain the highest risk of VTE in Black groups. In-depth studies across diverse ethnic populations are needed to unravel the whole genetics of VTE, which will help developing individual risk prediction models and strategies to minimise VTE in all populations.

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“…2). In included 62 articles-two articles were published by Australian scientists and they analyzed C677T polymorphism in three populations [25,26] and 3 articles were published from African region, investigated total seven populations [25,27,28]. Five articles with twelve populations were published from South America [29][30][31][32][33] (Table 2).…”

Section: Characteristic Of Eligible Studiesmentioning

confidence: 99%

Distribution of MTHFR C677T Gene Polymorphism in Healthy North Indian Population and an Updated Meta-analysis

et al. 2016

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Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of folate pathway. Several polymorphisms were reported in gene but C677T polymorphism is most studied and it has been reported to be risk factor for several diseases/disorders. The present study was designed to explore the frequency of C677T polymorphism in North Indian healthy population. In addition to this a meta-analysis of published articles was also performed to estimate the global prevalence of C677T polymorphism. A total of 1000 unrelated healthy subjects were selected for C677T polymorphism analysis. Different databases were searched for eligible articles. Prevalence proportion with 95 % CI was used to determine global prevalence of T allele and TT genotype. Meta-analysis was performed by Open meta-analyst. In 1000 blood samples analyzed, the frequency of T allele and TT genotype was 11 and 1 % respectively. Results of the meta-analysis showed that the global prevalence of T allele and TT genotype were 24.0 % (95 % CI 21.7-26.5) and 7.7 % (95 % CI 6.5-8.9) respectively. In sub-group meta-analysis, the lowest frequency of T allele was found in Africans (10.3 %; 95 % CI 3.8-16.8), and highest in Europeans (34.1 %; 95 % CI 31.9-36.3). The frequency of T allele in the North India is 11 %. The results of the meta-analysis showed that the frequency of the T allele and the TT genotype of C677T is highest in the Caucasian population.

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An Arab selective gradient in the distribution of factor V G1691A (Leiden), prothrombin G20210A, and methylenetetrahydrofolate reductase (MTHFR) C677T

Cited by 20 publications

References 10 publications

Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebanese and Bahraini Arabs

Differential contribution of MTHFR C677T variant to the risk of diabetic nephropathy in Lebanese and Bahraini Arabs

Ethnic diversity in the genetics of venous thromboembolism

Distribution of MTHFR C677T Gene Polymorphism in Healthy North Indian Population and an Updated Meta-analysis

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