“…For example, in the liver of adult male rats the glycogenolytic effect of CATs can proceed through a calciumlinked, cAMP-independent, α 1 -adrenergic mechanism. However, the same effect may take place by a predominantly β-adrenergic, cAMPdependent mechanism in the liver of female and fetal rats and in male rats in response to a variety of physiological (e.g., aging, fasting, liver regeneration), surgical (e.g., partial hepatectomy, adrenalectomy), pathological (e.g., glucocorticoid deficiency, malignant transformation, cholestasis, hypothyroidism) and experimental (e.g., animal species, incubation of the isolated cells in a serum-free medium) conditions (Erraji-Benchekroun et al 2005;Ishac and Kunos 1986;Kunos et al 1984).…”