An association between adropin hormone and total testosterone in obese men: a case-control study

Muhammed, Asmaa A.; Eid, Rania M. H. M.; Mohammed, Wafaa Salah; Abdel-Fadeil, Mahmoud R.

doi:10.1186/s12902-022-01102-7

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…Additionally, being a single-center study with a small patient sample, the findings need confirmation through larger, prospective studies, including nondiabetic populations. Muhammed AA et al, 2022 [ 108 ] Case-Control study Patients with normal weight and obese Sample Size: Case: 43, Control: 40 (Egypt) Adropin levels were significantly lower in obese men compared to those with normal weight. Adropin had a significant negative correlation with TC, TG, and LDL-c levels, but showed a significant positive correlation with HDL-c levels.…”

Section: Physiological Functions Of Adropinmentioning

confidence: 99%

Adropin: A crucial regulator of cardiovascular health and metabolic balance

Rooban,

Arul Senghor,

Vinodhini

et al. 2024

Metabolism Open

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Section: Physiological Functions Of Adropinmentioning

confidence: 99%

Adropin: A crucial regulator of cardiovascular health and metabolic balance

Rooban,

Arul Senghor,

Vinodhini

et al. 2024

Metabolism Open

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“…Adiponectin also promotes insulin sensitivity [ 201 ]. Adiponectin concentration in the seminal fluid was found less in subjects who were obese and overweight in comparison to individuals having normal weight [ 198 , 202 ].…”

Section: Reviewmentioning

confidence: 99%

Obesity: A Doorway to a Molecular Path Leading to Infertility

Ahmad¹,

Haque²

2022

Cureus

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The dramatic rise in obesity has recently made it a global health issue. About 1.9 billion were overweight, and 650 million global populations were obese in 2016. Obese women suffer longer conception time, lowered fertility rates, and greater rates of miscarriage. Obesity alters hormones such as adiponectin and leptin, affecting all levels within the hypothalamic-pituitary-gonadal axis. Advanced glycation end products (AGEs) and monocyte chemotactic protein-1 (MCP-1) are inflammatory cytokines that may play an important role in the pathophysiology of ovarian dysfunction in obesity. In obese males, there are altered sperm parameters, reduced testosterone, increased estradiol, hypogonadism, and epigenetic modifications transmitted to offspring. The focus of this article is on the possible adverse effects on reproductive health resulting from obesity and sheds light on different molecular pathways linking obesity with infertility in both female and male subjects. Electronic databases such as Google Scholar, Embase, Science Direct, PubMed, and Google Search Engine were utilized to find obesity and infertility-related papers. The search strategy is detailed in the method section. Even though multiple research work has shown that obesity impacts fertility in both male and female negatively, it is significant to perform extensive research on the molecular mechanisms that link obesity to infertility. This is to find therapeutics that may be developed aiming at these mechanisms to manage and prevent the negative effects of obesity on the reproductive system.

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Serum adropin is unaltered in adolescents with histology‐confirmed steatotic liver disease

Bays,

Bartlett,

Boone

et al. 2024

J. pediatr. gastroenterol. nutr.

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ObjectivesMetabolic dysfunction‐associated steatotic liver disease (MASLD) in adolescents is increasing. Adropin is a liver‐derived peptide involved in glucose and lipid homeostasis that was shown to be reduced in adults with metabolic disorders and cardiovascular disease (CVD). Serum adropin may also be higher in young men than women. A prior study reported that serum adropin was reduced in adolescents with MASLD, but the relationship between liver histology and CVD risk factors was not reported. We tested the hypotheses that adropin is (1) reduced in adolescents with MASLD compared to adolescents with obesity (Ob) or normal weight (NW) without MASLD, (2) correlated with blood pressure, arterial stiffness, and liver histopathology, and (3) higher in boys than girls.MethodsSerum adropin was measured in 47 patients with MASLD, and 27 and 29 control participants with Ob or NW, respectively.ResultsAdropin was not reduced but was instead 5% and 20% higher (p > 0.42) in the MASLD compared to the Ob and NW groups, respectively. Adropin concentration was not correlated with arterial stiffness or blood pressure. Adropin was 20% higher in boys than girls in the entire study cohort (p = 0.034). This difference was evident in the Ob group (p = 0.018), but not in the NW (p = 0.537) or the MASLD (p = 0.893) groups. Adropin was positively correlated with age within the MASLD group only (r = 0.46, p < 0.001).ConclusionSerum adropin was not reduced in adolescents with Ob or MASLD as reported previously. The positive relationship between age and adropin in adolescents with MASLD requires further examination.

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An association between adropin hormone and total testosterone in obese men: a case-control study

Cited by 4 publications

References 51 publications

Adropin: A crucial regulator of cardiovascular health and metabolic balance

Adropin: A crucial regulator of cardiovascular health and metabolic balance

Obesity: A Doorway to a Molecular Path Leading to Infertility

Serum adropin is unaltered in adolescents with histology‐confirmed steatotic liver disease

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