An association study of a functional catalase gene polymorphism, −262C→T, and patients with Alzheimer's disease

Relationships between single nucleotide polymorphisms of antioxidant enzymes and disease

“…In contrast, a Russian study reported no direct association between the C-262T SNP and asthma, although an indirect association between the C allele and asthma due to a positive linkage disequilibrium with the A-21T SNP was speculated (Polonikov et al, 2009). Finally, there was no association between the C-262T polymorphism and Alzheimer's disease (Goulas et al, 2002), depressive illness (Galecki et al, 2009), systemic lupus erythematosus (D'Souza et al, 2008), chronic kidney disease and its progression (Crawford et al, 2011, in press), and acute renal failure (Perianayagam et al, 2007).…”

rs2070424 of the SOD1 gene is associated with risk of Alzheimer's disease

“…There are only few studies evaluating the importance of ADS gene single nucleotide polymorphisms (SNPs) as risk factors of AD. So far, there were two studies evaluating the significance of one SNP of the catalase gene (rs1001179) [4,5], one -the significance of four SNPs of the SOD2 gene (rs2758346, r4880, rs2855116 and rs5746136) [6] and another one evaluating the significance of the rs1050450 SNP of the GPx-1 gene [7]. Only the study on the SOD2 gene, yielded positive results.…”

Investigation of antioxidant enzyme polymorphism in chronic obstructive pulmonary disease patients

“…DNA fragments were stained with ethidium bromide and then visualized under UV and genotyped. The T allele gives a band at 340 bp, Callele two bands at 185 and the 155 bp [16].…”