An attempt to extend ordinary capillary gas chromatography to supercritical fluid chromatography (SFC)

Grob, Konrad

doi:10.1002/jhrc.1240060403

Cited by 10 publications

(2 citation statements)

References 13 publications

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“…cSFC was also an extension of the GC in terms of instrumentation. Indeed the main GC features (a) capillary column, (b) oven, and (c) GC detectors mostly flame ionization detector (FID) were preserved in cSFC [227][228][229]. Only a few modifications of the GC hardware were required to work properly with supercritical fluid.…”

Section: Description Of Sfcmentioning

confidence: 99%

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Fekete¹,

Perrenoud²,

Guillarme

2014

CCHG

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Abstract:The current trend in high performance liquid chromatography (HPLC) tends toward the achievement of higher separation efficiency and shorter analysis time. Indeed, better performance in LC has become increasingly important in recent years mainly driven by the challenges of either analyzing more complex samples or increasing the numbers of samples per time unit. In the recent development of particle technology, the use of fully porous sub-2 m particles and sub-3 m shell particles have received considerable attention. Beside packed columns, the new generation of silica-based monolithic columns also offers very high separation power. However, to take full advantage of these innovative phases, the chromatographic system has also to be drastically optimized in terms of upper pressure limit and system volume.This revolution in column technology now spreads and covers several modes of liquid chromatography such as reversedphase liquid chromatography (RPLC), hydrophilic interaction liquid chromatography (HILIC), or even supercritical fluid chromatography (SFC). The HILIC and SFC, which can be considered as alternative modes of chromatography, could also be useful to extend the applicability of chromatography towards the analysis of very hydrophilic and lipophilic compounds, respectively.The present review gives an insight about the theory behind the success of current column technology and presents a summary of latest applications, using various modes of one-dimensional chromatography (RPLC, HILIC, SFC). This paper also shows that theoretically expected column efficiency could sometimes be compromised in practical work especially in the case of narrow bore columns.

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Section: Description Of Sfcmentioning

confidence: 99%

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Fekete¹,

Perrenoud²,

Guillarme

2014

CCHG

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“…It can also work as a traditional split/splitless (S/SL) injector or mimic an OCI. Even though several works, mainly on TAGs analysis , have obtained a comparable (or even superior ) performance using a PTV injector, the application of the latter as an alternative to OCI, in particular in the fats and oil analysis, is still limited and often criticized.…”

Section: Introductionmentioning

confidence: 99%

Comparison of different injection modes in edible oil minor components analysis

Purcaro

Barp

2015

J of Separation Science

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Waxes and fatty acid alkyl esters are minor components used as official parameters to control the authenticity and quality of a high-value olive oil product. A poor measurement can lead to a misleading classification of the oil. The official method requires their analysis together by capillary gas chromatography equipped with a flame ionization detector and an on-column injector to avoid discrimination and thermal degradation. The degradation can occur to a different extent if different (and not properly optimized) injectors are used. However, other injection techniques, such as programmed-temperature vaporizer, are much more versatile and more widespread. The aim of the present work was to compare the performance of a programmed-temperature vaporizer injector, in on-column and splitless mode, with the on-column injector to analyze alkyl esters and waxes. Discrimination among high-boiling compounds was evaluated, as well as the occurrence of thermal degradation, especially of sterols and diterpene alcohol (phytyl and geranylgeraniol) esters. A proper optimization of a programmed-temperature vaporizer injection, with particular attention to the liner selection, was proven to provide comparable results to the traditional on-column injection. A performance comparison was carried out both on standard mixtures and on real oil samples.

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Simultaneous coupling of capillary supercritical fluid chromatography and high temperature glass capillary gas chromatography to a mass spectrometer

Blum

Grolimund

Jordi

et al. 1988

J. High Resol. Chromatogr.

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SummaryThe coupling of glass capillary supercritical fluid chromatography to a high temperature GC/MS system via a micrometeradjustable glass capillary interface including an integrated pressure restrictor is described. With this coupling device, both complementary capillary chromatographic methods retain their full independence and flexibility.It is shown that in supercritical fluid chromatographyglassfulfils all the requirements of a suitable support material. The preparation of narrow bore glass capillary columns (0.06 mm i.d.),coatedwithchemicallybondedandcrosslinkedfluidswitha film thickness of about 0.6 p, which exploit the merits of OHterminated polysiloxanes as stationary phases is discussed. The application of glass capillary SFC is demonstrated and compared with examples given in the literature.

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An attempt to extend ordinary capillary gas chromatography to supercritical fluid chromatography (SFC)

Cited by 10 publications

References 13 publications

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Evolution and Current Trends in Liquid and Supercritical Fluid Chromatography

Comparison of different injection modes in edible oil minor components analysis

Simultaneous coupling of capillary supercritical fluid chromatography and high temperature glass capillary gas chromatography to a mass spectrometer

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