An Attempt to Optimize Supercritical CO2 Polyaniline-Polycaprolactone Foaming Processes to Produce Tissue Engineering Scaffolds

Montes, A.; Valor, Diego; Delgado, Laura; Pereyra, C.; Ossa, E.J. Martı́nez de la

doi:10.3390/polym14030488

Cited by 8 publications

(4 citation statements)

References 53 publications

(64 reference statements)

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“…The buffer was refreshed weekly. The weight loss rate was calculated using eqn (3), 42 where W 0 and W are the initial and final dry weight of the scaffolds:…”

Section: Methodsmentioning

confidence: 99%

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Adler,

Monavari,

Abraham

et al. 2023

RSC Adv.

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“…The buffer was refreshed weekly. The weight loss rate was calculated using eqn (3), 42 where W 0 and W are the initial and final dry weight of the scaffolds:…”

Section: Methodsmentioning

confidence: 99%

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Adler,

Monavari,

Abraham

et al. 2023

RSC Adv.

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“…The degradation ratio of the scaffolds was calculated based on Eq. 2 ( Montes et al, 2022 ):

where the initial weight (W i ) is the weight of the ADA-GEL scaffold at its maximum equilibrated swollen weight, and W w is the wet weight of the scaffolds at predetermined time interval.…”

Section: Methodsmentioning

confidence: 99%

Mussel-inspired polydopamine decorated alginate dialdehyde-gelatin 3D printed scaffolds for bone tissue engineering application

Ghorbani

Kim

Monavari

et al. 2022

Front. Bioeng. Biotechnol.

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This study utilized extrusion-based 3D printing technology to fabricate calcium-cross-linked alginate dialdehyde-gelatin scaffolds for bone regeneration. The surface of polymeric constructs was modified with mussel-derived polydopamine (PDA) in order to induce biomineralization, increase hydrophilicity, and enhance cell interactions. Microscopic observations revealed that the PDA layer homogeneously coated the surface and did not appear to induce any distinct change in the microstructure of the scaffolds. The PDA-functionalized scaffolds were more mechanically stable (compression strength of 0.69 ± 0.02 MPa) and hydrophilic (contact angle of 26) than non-modified scaffolds. PDA-decorated ADA-GEL scaffolds demonstrated greater durability. As result of the 18-days immersion in simulated body fluid solution, the PDA-coated scaffolds showed satisfactory biomineralization. Based on theoretical energy analysis, it was shown that the scaffolds coated with PDA interact spontaneously with osteocalcin and osteomodulin (binding energy values of −35.95 kJ mol−1 and −46.39 kJ mol−1, respectively), resulting in the formation of a protein layer on the surface, suggesting applications in bone repair. PDA-coated ADA-GEL scaffolds are capable of supporting osteosarcoma MG-63 cell adhesion, viability (140.18% after 7 days), and proliferation. In addition to increased alkaline phosphatase secretion, osteoimage intensity also increased, indicating that the scaffolds could potentially induce bone regeneration. As a consequence, the present results confirm that 3D printed PDA-coated scaffolds constitute an intriguing novel approach for bone tissue engineering.

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“…Therefore, supercritical foaming technology is a promising area for research and development. Recent trends include the preparation of microporous scaffolds [ 7 , 8 , 9 ] and the production of rubber foams [ 10 ]. However, there are many shortcomings in this technology.…”

Section: Introductionmentioning

confidence: 99%

Applications and Challenges of Supercritical Foaming Technology

2023

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With economic development, environmental problems are becoming more and more prominent, and achieving green chemistry is an urgent task nowadays, which creates an opportunity for the development of supercritical foaming technology. The foaming agents used in supercritical foaming technology are usually supercritical carbon dioxide (ScCO2) and supercritical nitrogen (ScN2), both of which are used without environmental burden. This technology can reduce the environmental impact of polymer foam production. Although supercritical foaming technology is already in production in some fields, it has not been applied on a large scale. Here, we present a detailed analysis of the types of foaming agents currently used in supercritical foaming technology and their applications in various fields, summarizing the technological improvements that have been made to the technology. However, we have found that today’s supercritical technologies still need to address some additional challenges to achieve large-scale production.

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An Attempt to Optimize Supercritical CO2 Polyaniline-Polycaprolactone Foaming Processes to Produce Tissue Engineering Scaffolds

Cited by 8 publications

References 53 publications

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Mussel-inspired polydopamine decorated silane modified-electroconductive gelatin-PEDOT:PSS scaffolds for bone regeneration

Mussel-inspired polydopamine decorated alginate dialdehyde-gelatin 3D printed scaffolds for bone tissue engineering application

Applications and Challenges of Supercritical Foaming Technology

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