An Autocrine Loop Involving Ret and Glial Cell–Derived Neurotrophic Factor Mediates Retinoic Acid–Induced Neuroblastoma Cell Differentiation

Cerchia, Laura; D’Alessio, Amelia; Amabile, Giovanni; Ducongé, Frédéric; Pestourie, Carine; Tavitian, Bertrand; Libri, Domenico; Franciscis, Vittorio de

doi:10.1158/1541-7786.mcr-06-0050

Cited by 31 publications

(32 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is well known that upon ATRA treatment BE(2)C cells show a decrease in the proliferation rate and neurite outgrowth [Bierau et al, 2002;Lee and Kim, 2004;Cerchia et al, 2006]. We observed that MF exposure significantly potentiated the effects of ATRA treatment.…”

Section: Discussionsupporting

confidence: 52%

See 1 more Smart Citation

Synergic effect of retinoic acid and extremely low frequency magnetic field exposure on human neuroblastoma cell line BE(2)C

Marcantonio

Franceschini

et al. 2010

Bioelectromagnetics

View full text Add to dashboard Cite

The aim of the present study was to assess whether exposure to a sinusoidal extremely low frequency magnetic field (ELF-MF; 50 Hz, 1 mT) can affect proliferation and differentiation in the human neuroblastoma cell line BE(2)C, which is representative of high risk neuroblastomas. Cells were subjected to ELF-MF exposure in the presence or absence of a neuronal differentiating agent (all-trans-retinoic acid, ATRA) for 24-72 h. In each experiment, ELF-MF-exposed samples were compared to sham-exposed samples. Cells exposed to ELF-MF combined with retinoic treatment showed a decreased cellular proliferation and an increased proportion of G(0)/G(1) phase cells compared to cells exposed to either treatment alone. Moreover, ELF-MF- and ATRA-treated cells showed more differentiated morphological traits (a higher neurite number/cell, an increased neurite length), together with a significant increase of mRNA levels of p21(WAF1/CIP1) and cdk5 genes, both involved in neuronal differentiation. In addition, the expression of cyp19 gene, which is involved both in neuronal differentiation and stress response, was evaluated; cyp19 gene expression was enhanced by ATRA treatment and significantly enhanced further by ELF-MF exposure combined with ATRA. In conclusion, our data suggest that ELF-MF exposure can strengthen ATRA effects on neuroblastoma cells.

show abstract

Section: Discussionsupporting

confidence: 52%

“…BE(2)C cell line is mainly composed of undifferentiated neuroblast-like cells, and can slightly differentiate toward a neuronal phenotype upon all-trans-retinoic acid (ATRA) treatment [Bierau et al, 2002;Lee and Kim, 2004;Cerchia et al, 2006;Jeong et al, 2006].…”

Section: Introductionmentioning

confidence: 99%

Synergic effect of retinoic acid and extremely low frequency magnetic field exposure on human neuroblastoma cell line BE(2)C

Marcantonio

Franceschini

et al. 2010

Bioelectromagnetics

View full text Add to dashboard Cite

show abstract

“…Many studies have concluded that RET plays a major role in differentiation and proliferation (21,51). It participates in a reciprocal loop between stromal mesenchyme and the ureteric bud epithelium; vitamin Adependent signals secreted by stromal cells control Ret expression in the ureteric bud.…”

Section: Discussionmentioning

confidence: 99%

The RET oncogene is a critical component of transcriptional programs associated with retinoic acid–induced differentiation in neuroblastoma

Oppenheimer¹,

Cheung²,

Gerald

2007

Molecular Cancer Therapeutics

View full text Add to dashboard Cite

show abstract

“…In the case of TLR2, a specific polymorphism (R753N) has been linked to increased susceptibility to tuberculosis (39). Interestingly, a different mutation associated with TLR2, upstream of the coding region, affects the development of asthma (40). Only children from farmers with this mutation show a reduced prevalence of asthma, linking TLR2 to the protective effects seen in rural populations vs urban populations (41).…”

Section: Tlr-mediated Signalingmentioning

confidence: 99%

How epithelial cells detect danger: aiding the immune response

Vroling

Fokkens

Drunen

2008

Allergy

View full text Add to dashboard Cite

The epithelial layer occupies a strategic important location between an organisms’ interior and exterior environment. Although as such it forms a physical barrier between both environments, it became clear that the role of the epithelium extends far beyond this rather passive role. Through specialized receptors and other more general mechanisms, the epithelial layer is not only able to sense changes in its environment but also to actively respond to these changes. These responses allow the epithelium to contribute to wound and tissue repair, to the defense against micro‐organisms, and to the control and regulation of the locale immune response. In this review, we focus on signals acting on epithelium from the exterior environment, how these signals are processed and identify research challenges.

show abstract

An Autocrine Loop Involving Ret and Glial Cell–Derived Neurotrophic Factor Mediates Retinoic Acid–Induced Neuroblastoma Cell Differentiation

Abstract: In several neuroblastoma cell lines,

Cited by 31 publications

References 33 publications

Synergic effect of retinoic acid and extremely low frequency magnetic field exposure on human neuroblastoma cell line BE(2)C

Synergic effect of retinoic acid and extremely low frequency magnetic field exposure on human neuroblastoma cell line BE(2)C

The RET oncogene is a critical component of transcriptional programs associated with retinoic acid–induced differentiation in neuroblastoma

How epithelial cells detect danger: aiding the immune response

Contact Info

Product

Resources

About