An automated GC/MS system for the analysis of volatile and semi‐volatile organic compounds in water

Vickers, Allen K.; Wright, Lowell M.

doi:10.1155/s1463924693000173

Cited by 6 publications

(1 citation statement)

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“…A membrane probe heated at 70°C in conjunction with a flow system for introducing the sample was tested for this purpose; 16 one other alternative uses a syringe autoinjector. 17 Sample pretreatment was not automated in either case, however. On-line GC/MS systems have been used for routine measurements of organic compounds in the atmosphere.…”

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An automated preparation device for the determination of drugs in biological fluids coupled on-line to a gas chromatograph/mass spectrometer

Cárdenas

Gallego

Valcárcel

1997

Rapid Commun. Mass Spectrom.

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An on-line, solid-phase extraction gas chromatography/mass spectrometry method for the automated pretreatment of biological fluids is proposed. Several drugs of abuse were used as model compounds. The analytes are trapped on a home-made RP-C 18 column and subsequently eluted with chloroform. The fraction of the organic solvent containing the largest drug concentration is injected into the CG/MS via a single interface. Detection limits of 0.5-10 ng/mL are achieved by using 1 mL of urine or serum; the relative standard deviation is ca. 3-4%. The selectivity of the method allows the analytes to be determined in the presence of other drugs of abuse. To demonstrate the potential of the proposed approach, the method was applied to the determination of cocaine, codeine and methadone in human urine obtained from patients in a hospital. © 1997

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confidence: 99%

An automated preparation device for the determination of drugs in biological fluids coupled on-line to a gas chromatograph/mass spectrometer

Cárdenas

Gallego

Valcárcel

1997

Rapid Commun. Mass Spectrom.

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Putting mass spectrometry in the hands of the end user

Pullen

Perkins

Burton

et al. 1995

J. Am. Soc. Mass Spectrom.

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The ease of use of the newer liquid chromatography-mass spectrometry interfaces has made possible the automated acquisition of spectra from large batch queues of samples. This fact, combined with the realization that unit molecular mass determination was the only datum desired by a majority of drug discovery synthetic chemists, led us to develop open access mass spectrometry in the early 1990s. Open access spectrometers now scan over 100,000 samples per year from synthesis laboratories at Pfizer. Our experiences with this novel use of mass spectrometry in a large research facility are discussed and we detail some of the pitfalls we believe to be common to this approach. In addition, we offer some reflection on the cultural changes we have observed in our research environment since this experiment began.

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Hyphenated pervaporation—solid-phase preconcentration—gas chromatography for the determination of volatile organic compounds in solid samples

Papaefstathiou

Castro

1997

Journal of Chromatography A

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An automated GC/MS system for the analysis of volatile and semi‐volatile organic compounds in water

Cited by 6 publications

References 0 publications

An automated preparation device for the determination of drugs in biological fluids coupled on-line to a gas chromatograph/mass spectrometer

An automated preparation device for the determination of drugs in biological fluids coupled on-line to a gas chromatograph/mass spectrometer

Putting mass spectrometry in the hands of the end user

Hyphenated pervaporation—solid-phase preconcentration—gas chromatography for the determination of volatile organic compounds in solid samples

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