An Early Development Budget Impact Model for the Use of Melatonin in the Treatment and Prevention of Osteoporosi

Khairnar, Corry D Bondi Rahul

doi:10.4172/2167-065x.1000132

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…The recent discovery of mitochondrial melatonin receptors 22,23 provides fertile ground for future research in understanding their role in melatonin-mediated processes in the body "in general" but especially in bone. These properties of melatonin coupled with its actions on the immune system, circadian entrainment, quality of life, safety profile, and cost 284 argues strongly for its use clinically to slow the progression of bone loss in "at risk" populations (eg, aging population, menopausal women, RA, shift workers) or augment bone mass in those with osteopenia, osteoporosis or who have suffered a fragility fracture.…”

Section: Discussionmentioning

confidence: 99%

Melatonin effects on bone: Implications for use as a therapy for managing bone loss

Munmun

Witt‐Enderby

2021

Journal of Pineal Research

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Melatonin is the primary circadian output signal from the brain and is mainly synthesized in pinealocytes. The rhythm and secretion of melatonin are under the control of an endogenous oscillator located in the SCN or the master biological clock.Disruptions in circadian rhythms by shift work, aging, or light at night are associated with bone loss and increased fracture risk. Restoration of nocturnal melatonin peaks to normal levels or therapeutic levels through timed melatonin supplementation has been demonstrated to provide bone-protective actions in various models. Melatonin is a unique molecule with diverse molecular actions targeting melatonin receptors located on the plasma membrane or mitochondria or acting independently of receptors through its actions as an antioxidant or free radical scavenger to stimulate osteoblastogenesis, inhibit osteoclastogenesis, and improve bone density. Its additional actions on entraining circadian rhythms and improving quality of life in an aging population coupled with its safety profile make it an ideal therapeutic candidate for protecting against bone loss in susceptible populations. The intent of this review is to provide a focused discussion on bone loss and disorders of the bone as it relates to melatonin and conditions that modify melatonin levels with the hope that future therapies include those that include melatonin and correct those factors that modify melatonin levels like circadian disruption.

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Section: Discussionmentioning

confidence: 99%

Melatonin effects on bone: Implications for use as a therapy for managing bone loss

Munmun

Witt‐Enderby

2021

Journal of Pineal Research

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“…Moreover, in recent years, the effects of melatonin on promoting bone formation have been increasingly reported and appear to differ from those of traditional antiosteoporosis drugs (bisphosphonates, denosumab, raloxifene, and teriparatide). Melatonin also has few adverse effects [15, 16], has a significant role in enhancing the growth of bone [17–20], and is cost-effective as a dietary supplement [21], making it an attractive candidate for further investigation. Additionally, the protecting function of melatonin against mitochondrial oxidative stress has been discovered among hepatocytes, cardiocytes, and oocytes [22–24].…”

Section: Introductionmentioning

confidence: 99%

Melatonin Increases Bone Mass around the Prostheses of OVX Rats by Ameliorating Mitochondrial Oxidative Stress via the SIRT3/SOD2 Signaling Pathway

Zhou

Liu

Shen

et al. 2019

Oxidative Medicine and Cellular Longevity

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Bone mass loss around prostheses is a major cause of implant failure, especially in postmenopausal osteoporosis patients. In osteoporosis, excess oxidative stress largely contributed abnormal bone remodeling. Melatonin, which is synthesized from the pineal gland, promotes osteoblast differentiation and bone formation and has effectively been used to combat oxidative stress. Thus, we determined if melatonin can inhibit oxidative stress to promote osteogenesis and improve bone mass around prostheses in osteoporosis. In this study, we observed that received melatonin at 50 mg/kg body weight significantly increased periprosthetic bone mass as well as implant fixation intensity in ovariectomized (OVX) rats. Meanwhile, it decreased the expression of oxidative stress markers (NAPDH oxidase 2 and cytochrome c) and enhanced expressing level of the formation markers of bones (alkaline phosphatase, osteocalcin, and osterix) around prostheses compared to that in the control group. Additionally, melatonin decreased hydrogen peroxide- (H2O2-) induced oxidative stress and restored the osteogenesis potential of MC3T3-E1 cells. Mechanistically, melatonin clearly increased mitochondrial sirtuin 3 (SIRT3) expression and decreased the ratio of acetylated superoxide dismutase 2 (AC-SOD2)/SOD2 compared to the H2O2 group. SIRT3 inhibition counteracted the protective effects of melatonin on oxidative stress and bone formation. Together, the results showed that melatonin ameliorated oxidative stress in mitochondrial via the SIRT3/SOD2 signaling pathway, thereby promoting osteogenesis, improving bone mass around the prostheses, and increasing initial stability. Thus, melatonin might be a suitable candidate to decrease the rate of implant failure and lengthen the lifespan of prostheses after total joint arthroplasty.

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Melatonin as a Nutraceutical

Cardinali

2016

Ma Vie en Noir

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An Early Development Budget Impact Model for the Use of Melatonin in the Treatment and Prevention of Osteoporosi

Cited by 5 publications

References 17 publications

Melatonin effects on bone: Implications for use as a therapy for managing bone loss

Melatonin effects on bone: Implications for use as a therapy for managing bone loss

Melatonin Increases Bone Mass around the Prostheses of OVX Rats by Ameliorating Mitochondrial Oxidative Stress via the SIRT3/SOD2 Signaling Pathway

Melatonin as a Nutraceutical

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