“…At the health system level, digital therapeutics can influence health care costs and resource use [ 41 , 47 , 48 , 53 , 69 , 71 , 72 , 80 , 81 , 94 , 95 , 105 , 107 , 111 , 113 , 121 , 124 , 128 , 131 , 133 , 147 , 153 , 154 , 160 , 164 , 171 , 172 , 180 , 189 , 207 , 211 , 212 , 228 , 231 , 232 , 237 , 238 , 255 - 258 , 261 , 262 , 265 , 269 , 273 ] and affect the workload and workflow of the health workforce, potentially bringing about significant improvements [ 19 , 47 , 60 , 62 , 78 , 80 , 90 , 105 , 116 , 124 , 126 , 128 , 134 , 146 , 147 , 176 , 188 , 194 , 196 , 221 , <...…”