An efficient and green synthesis of novel benzoxazole under ultrasound irradiation

Abstract

Ultrasound as green process and an alternative energy source was investigated for the environmentally benign synthesis of novel benzoxazoles from different azo-linked salicylic acid derivatives and 2-amino-4-chlorophenol in short reaction time and high yield. These benzoxazole compounds have been characterized by elemental analysis, FT-IR, (1)H NMR and (13)C NMR spectroscopy.

Discovery of Novel Sulfonamide‐Based 5‐Arylidenerhodanines as Effective Carbonic Anhydrase (II) Inhibitors: Microwave‐Assisted and Ultrasound‐Assisted One‐Pot Four‐Component Synthesis, Molecular Docking, and Anti‐CA II Screening Studies

“…In both multistep and one‐pot MCRs, N ‐substituted‐5‐arylidenerhodanines are generally obtained from the base catalyzed Knoevenagel reaction of various aldehydes with N ‐substituted rhodanines, the synthesis of which are carried out by a one‐pot three‐component condensation of amine, chloroacetic acid, and carbon disulfide . For his purpose, a great deal of MW‐based techniques are reported , while only one straightforward US‐mediated synthesis for rhodanines was reported . The based catalyst Knoevenagel reaction leading to the condensation of rhodanines with aldehydes was carried out in separate steps .…”

“…So far, notable efforts were dedicated to the development of green and economical methods leading to the formation of arylidenerhodanines. Nevertheless, the one‐pot multicomponent preparation of these compounds remained a very challenging task because some undesired conditions such as the use of a phosphine catalyst or chromatographic separation could be a demanding operation of workup .…”

Potassium 2-oxoimidazolidine-1,3-diide: An effective and new catalyst for the grinding synthesis of (1H-indol-3-yl)methyl-2H-indan-1,3-diones

“…As part of our ongoing interest for the development of efficient and environmentally friendly procedures for the synthesis of heterocyclic and pharmaceutical compounds [19][20][21][22][23][24][25], herein we wish to report our experimental results on the synthesis of new generation of 2H-indene-1,3-dione using various aromatic aldehydes, indole, 1,3-indandione in the presence of novel catalyst (POImD) (Scheme 1) and the results were listed in Table 1. With the best catalyst in hand, we moved to study the effects of catalyst amount on the model reaction and the results were listed in Table 2.…”

Green Synthesis of Pyrazolo‐thiazolidine‐4‐ones Using Magnetic Nanocomposite of Multiwalled Carbon Nanotube

“…In continuation of our ongoing studies to synthesize the heterocyclic and pharmaceutical compounds at mild and practical protocols , herein, we report our experimental results on synthesis of 2‐pyrazolo‐3‐phenyl‐1,3‐thiazolidine‐4‐ones using various synthetized pyrazolecarbaldehydes, anilines, and thioglycolic acid in the presence of mMWCNT nanocomposite at room temperature (Scheme ).…”