An efficient and modified biginelli one‐pot synthesis of new isoxazole substitted 3,4‐dihydropyrimidin‐2(1H)‐ones and thiones catalyzed by VCl₃

Abstract

An efficient and modified Biginelli one‐pot synthesis of new‐isoxazole substituted 3,4‐dihydropyrimidin‐2(1H)‐ones and thiones from aromatic aldehydes, ketoamide and urea/thiourea in acetonitrile using VCl3 as the catalyst is described.

A microwave-assisted synthesis of 3,4-dihydropyrimidin-2(1H)-one/thione derivatives using nanocrystalline MgFe2O4 as catalyst

“…Few important catalysts are ionic liquids [4], H3BO3 [5], VCl3 [6], Sr(OTf)2 [7], poly(4-vinylpyridinium)hydrogen sulphate [8], LaCl3-graphite [9], ZrO2 [10], sulfated tungstate [11]. These processes are quite costlier, time consuming and environmental unfriendly.…”