An efficient approach to the synthesis of some novel heterocycles related to indoline moiety using [BMIm]Cl catalysis

Abstract

The combination of isatins, active methylene reagents and 4-phenylurazole/ phthalhydrazide in the presence of ionic liquid ([BMIm]Cl) as a solvent catalyst was found to be a suitable and efficient method for the synthesis of the biologically important spirooxindoles. The features of this procedure were characterized by one-pot procedure, reasonable reaction times, fairly high yields, and simple isolation procedures. The ionic liquid can be easily separated and reused for several times. KEYWORDS Ionic liquidMulti-compound reactions Spirooxindole Isatin Pyrazole Graphical AbstractAn efficient approach to the synthesis ...

Highly efficient and green approach for the synthesis of spirooxindole derivatives in the presence of novel Brønsted acidic ionic liquids incorporated in UiO‐66 nanocages

“…ILs, as a new class of catalysts or solvents, have recently attracted increasing research attention because of their unique properties such as non‐flammability, non‐volatility, reusability, negligible vapour pressure, high thermal stability and wide liquid range . ILs have found applications in Diels–Alder reactions, alkylation, Michael addition, nitration, esterification, etc .…”

A Rapid and Highly Effectual Protocol for the Synthesis of Bis-coumarins using Triethylaminium-N-sulfonic Acid Tetrachloroaluminate under Solvent-Free Conditions

“…These compounds are of importance in organic synthesis field and extensively used as solvent, reagent and catalyst [1][2][3][4][5][6][7][8][9]. These extensive applications are related to their unique properties such as suitable thermal and chemical stability, non-volatility, wide liquid-state temperature range, nonflammability, large electrochemical window, enhanced reactivity, favorable salvation behavior, and aptitude to modify physical and chemical properties with functionalization of their cation and anion [1][2][3][4][5][6][7][8][9]. Among the kinds of ILs, protic acidic ones are appropriate candidate to utilize as effective catalysts for organic transformations [4][5][6][7][8][9].…”

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“…Chemical and physical characteristics of the RTILs are adaptable by changing their cation and anion [1]. In consideration of the excellent physicochemical characteristics of ILs, they have been used in lithium batteries [2], electrode position [3], solar cells [4], and electric double layer capacitors [5], and as solvent, reagent and catalyst in organic synthesis [6][7][8][9][10][11][12]. It should be mentioned that protic acidic ILs, as an important class of ionic liquids, could be applied as catalysts for a wide range of organic transformations [8][9][10][11][12][13][14].…”