An efficient, catalyst-free and aqueous ethanol-mediated synthesis of 5-((2-aminothiazol-5-yl)(phenyl)methyl)-6-hydroxypyrimidine-2,4(1H,3H)-dione derivatives and their antioxidant activity

Abstract

This study aimed to develop the multicomponent synthesis of 5-((2-aminothiazol-5-yl)(phenyl)methyl)-6-hydroxypyrimidine-2,4(1H,3H)-dione derivatives via a catalyst-free approach and their biological assay.

In silico exploration of acetic acid driven multicomponent synthesis: design, characterization, and antioxidant evaluation of spiroacridines and spiroquinolines

“…Reactive oxygen species (ROS) play an integral role in the development of many major illnesses, including cancer, diabetes, arteriosclerosis, heart disease, and cataracts. 1 The detrimental effects of free radicals that may cause biological damage are referred to as oxidative stress. Free radicals have a pathogenic role in the development of a wide range of chronic degenerative illnesses in humans, including cancer and autoimmune, inflammatory, and cardiovascular neurodegenerative disorders.…”

“…In continuation to our efforts towards the construction of novel spiro molecules, 16,23–26 herein, we explored a metal-free multicomponent synthesis 1,27–29 of spiroacridines and spiroquinolines via a one-pot reaction of 3,4-methylenedioxyaniline, isatin and cyclic 1,3-diones in the presence of glacial acetic acid, which is vital for sustainability (Scheme 1). To acquire theoretical insights, the frontier molecular orbital (FMO), the molecular electrostatic potential (MEP), and several quantum chemical descriptors (QCDs) were computed using the DFT using the B3LYP/6-311G+(d,p) basis set.…”

“…It has encouraged the synthetic community to seek out more environmentally friendly syntheses and reactions in order to speed up preparation while using less energy and effort. 1,8…”