An efficient four-component synthesis of dithiocarbamate derivatives

Recent advances in the application of deep eutectic solvents as sustainable media as well as catalysts in organic reactions

“…The one-pot reaction of various aromatic aldehydes, ketones, aliphatic amines, and carbon disulde, in the presence of potassium hydroxide in ChCl/urea at room temperature, led to the corresponding dithiocarbamates (138) in good to excellent yields (Scheme 51). 100 In this MCR, ChCl/urea showed a signicant benecial effect on the reaction yields compared to classical organic solvents (THF or CH 2 Cl 2 ) and water.…”

Deep Eutectic Solvents (DESs) and Their Applications

“…DESs have been used to catalyze a one-pot synthesis of nitriles from aldehydes, 2 H -indazolo­[2,1- b ]­phthalazine-triones, the synthesis of phenols, and pyran and benzopyran derivatives . DESs have been utilized in the Paal–Knorr reactions and the synthesis of amino acid dithiocarbamates, aurones, xanthanes and tetraketones, dithiocarbamate derivatives, peptides, 1,4-dihydropyridine derivatives, 3,4-dihydro-2­( H )-pyrimidinones, polysubstituted imidazoles, and N-substituted pyrroles …”

Deep Eutectic Solvents: The Organic Reaction Medium of the Century

“…The reaction proceeds smoothly at room temperature and in a short reaction periods, the DES being recyclable only for two additional runs, since a considerable drop in yield was observed afterwards. [115] Finally, other interesting type of multicomponent transformations involving sulphur compounds carried out in a DES medium are those concerning the use of thiourea as odourless sulphur source. Thus, the reaction of thiourea with alkyl halides in the ChCl-urea mixture afforded the corresponding isothiouronium salt, which generated the corresponding thiolate along with urea (incorporated to the DES mixture) after basic hydrolysis.…”